A geometric correction scheme for spatial leakage effects in MEG/EEG seed-based functional connectivity mapping

Human Brain Mapping
Vincent WensXavier De Tiège

Abstract

Spatial leakage effects are particularly confounding for seed-based investigations of brain networks using source-level electroencephalography (EEG) or magnetoencephalography (MEG). Various methods designed to avoid this issue have been introduced but are limited to particular assumptions about its temporal characteristics. Here, we investigate the usefulness of a model-based geometric correction scheme (GCS) to suppress spatial leakage emanating from the seed location. We analyze its properties theoretically and then assess potential advantages and limitations with simulated and experimental MEG data (resting state and auditory-motor task). To do so, we apply Minimum Norm Estimation (MNE) for source reconstruction and use variation of error parameters, statistical gauging of spatial leakage correction and comparison with signal orthogonalization. Results show that the GCS has a local (i.e., near the seed) effect only, in line with the geometry of MNE spatial leakage, and is able to map spatially all types of brain interactions, including linear correlations eliminated after signal orthogonalization. Furthermore, it is robust against the introduction of forward model errors. On the other hand, the GCS can be affected by local o...Continue Reading

References

Jan 1, 1994·Medical & Biological Engineering & Computing·M S Hämäläinen, R J Ilmoniemi
Sep 1, 1997·IEEE Transactions on Bio-medical Engineering·B D Van VeenA Suzuki
Sep 24, 1999·NeuroImage·K J FristonK J Worsley
Jun 14, 2000·IEEE Transactions on Bio-medical Engineering·R VigárioE Oja
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J GrossR Salmelin
Mar 1, 2002·Human Brain Mapping·Arthur K LiuJohn W Belliveau
Dec 3, 2003·The Journal of Physiology·Bettina PollokAlfons Schnitzler
Jul 14, 2004·IEEE Transactions on Bio-medical Engineering·Luca FaesGiandomenico Nollo
Sep 8, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Guido NolteMark Hallett
Jan 18, 2005·NeuroImage·Bettina PollokAlfons Schnitzler
Apr 23, 2005·Human Brain Mapping·Arjan HillebrandGareth R Barnes
Mar 18, 2006·NeuroImage·Ming-Xiong HuangRoland R Lee
Apr 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karim JerbiSylvain Baillet
Nov 13, 2007·NeuroImage·Karl FristonJérémie Mattout
Jul 8, 2008·NeuroImage·David Wipf, Srikantan Nagarajan
Jul 8, 2008·NeuroImage·Wanmei OuPolina Golland
Oct 18, 2008·Epilepsy Research·Xavier De TiègePatrick Van Bogaert
Feb 25, 2009·Human Brain Mapping·Jan-Mathijs Schoffelen, Joachim Gross
Mar 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Francesco de PasqualeMaurizio Corbetta
Jan 25, 2011·NeuroImage·Mathieu BourguignonVeikko Jousmäki
Mar 1, 2011·Seizure : the Journal of the British Epilepsy Association·Evelien CarretteXavier De Tiège
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew J BrookesPeter G Morris
Oct 4, 2011·NeuroImage·Mathieu BourguignonXavier De Tiège
Mar 24, 2012·Trends in Cognitive Sciences·Satu Palva, J Matias Palva
May 9, 2012·Nature Neuroscience·Joerg F HippAndreas K Engel
May 29, 2012·Neuron·Francesco de PasqualeMaurizio Corbetta
Apr 3, 2013·NeuroImage·Mark W WoolrichIead Rezek
Jan 15, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Vincent WensXavier De Tiège

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Citations

Dec 9, 2015·Journal of Neuroscience Methods·Khalid HamandiKrish D Singh
Mar 24, 2016·Behavioural Brain Research·Gennady G KnyazevAlexander E Saprigyn
Jun 6, 2016·NeuroImage·G L ColcloughS M Smith
Sep 19, 2016·NeuroImage·George C O'NeillMatthew J Brookes
Feb 6, 2017·Neuroscience·Gennady G KnyazevValentina V Stepanova
Jan 15, 2020·Journal of Cognitive Neuroscience·Maxime NiesenXavier De Tiège
Aug 18, 2020·PLoS Computational Biology·D PascucciG Plomp
Mar 10, 2018·Frontiers in Human Neuroscience·Rachel C LeungMargot J Taylor
Aug 22, 2018·Frontiers in Neuroscience·Stavros I DimitriadisKrish D Singh
Nov 12, 2019·Frontiers in Neuroscience·Stefania Della PennaFrancesco de Pasquale
Jun 13, 2020·Frontiers in Integrative Neuroscience·Tim CoolenXavier De Tiège
Sep 5, 2020·Network Neuroscience·Katharina GlombPatric Hagmann
Feb 6, 2020·Frontiers in Computational Neuroscience·Marios AntonakakisGeorge Zouridakis
Dec 20, 2019·Annals of Clinical and Translational Neurology·Gilles NaeijeXavier P De Tiège
Nov 27, 2020·Human Brain Mapping·Martin SjøgårdXavier De Tiège
Mar 22, 2021·NeuroImage·Paul de LangeMathieu Bourguignon
Apr 6, 2021·NeuroImage·F de PasqualeS Della Penna
Jul 24, 2021·Cerebral Cortex Communications·Amandine Van RinsveldAlain Content
Sep 16, 2021·Human Brain Mapping·Gilles NaeijeXavier De Tiège

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