A Giant Brunneroma Causing Gastrointestinal Bleeding and Severe Anemia Requiring Transfusion and Surgery

Case Reports in Surgery
Nicola C FrenkelJeroen Hagendoorn


Brunner's gland hamartoma, also called hyperplasia, adenoma, and Brunneroma, is an extremely rare benign proliferative lesion of Brunner's glands in the duodenum. While being mostly small and asymptomatic, they can result in gastrointestinal bleeding and obstruction. We report the case of a 54-year-old man presenting with melena and severe anemia requiring blood transfusion. CT scans showed a large mass of 8 cm in diameter, presumably arising in the duodenum. Endoscopic biopsies were not conclusive. As we were unable to determine the nature of the mass preoperatively and due to the severe symptoms, its size, and the uncertain malignant potential, a classic Whipple procedure was performed. The resected specimen showed extensive proliferation of Brunner's glands without signs of malignancy.


Feb 1, 1977·American Journal of Surgery·S de Silva, P Chandrasoma
Mar 1, 1986·Journal of the Royal Society of Medicine·K ShorrockR D Leach
Dec 17, 1998·Journal of Clinical Gastroenterology·J ZangaraG Fantry
Feb 15, 2001·Gastrointestinal Endoscopy·M TaiM Otsuki
Apr 25, 2001·Journal of Clinical Gastroenterology·D YadavC S Pitchumoni
May 8, 2002·Journal of Gastroenterology·Kimishige AkinoKohzoh Imai
Jun 5, 2002·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·David R StolpmanDeepak V Gopal
Aug 5, 2003·Postgraduate Medical Journal·M J BrookesM Cox
Nov 1, 1961·American Journal of Clinical Pathology·L SILVERMANE G HARRISON
Aug 10, 2004·World Journal of Gastroenterology : WJG·Yu-Ping GaoWen-Jun Zheng
Apr 13, 2006·World Journal of Gastroenterology : WJG·Alba RoccoGerardo Nardone
May 31, 2006·Gastrointestinal Endoscopy·Soichi ItabaKazuhiko Nakamura
Aug 24, 2006·Digestive Diseases and Sciences·Yang-Yuan ChenHsu-Heng Yen
Aug 25, 2006·AJR. American Journal of Roentgenology·Nandini D PatelLeslie H Sobin
Sep 7, 2006·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Edy StermerAlexandra Lavy
Dec 16, 2006·Digestive Diseases and Sciences·Reina OhbaSumio Watanabe
May 14, 2008·Southern Medical Journal·Ravi R KurellaRichard Harty
Apr 14, 2009·Journal of Pediatric Surgery·Ikbel El FalehAndreas Nydegger
Sep 4, 2009·World Journal of Surgical Oncology·Zoe A StewartChristopher L Wolfgang
Sep 8, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emad QayedRobin Rutherford
Oct 19, 2011·Cytopathology : Official Journal of the British Society for Clinical Cytology·T Stoos-VeicG Aralica
Jan 19, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Soumil VyasGeorge Webster
Jul 28, 2012·Digestive Diseases and Sciences·Kyungeun KimEunsil Yu
Oct 13, 2012·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Yun-Shi ZhongShi-Yao Chen
Dec 26, 2013·Gastrointestinal Endoscopy·Tasuku NakaboriTetsuo Takehara
Sep 26, 2014·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Jian LiuTong Yu Tang
Apr 1, 2015·Gastroenterology·Tsutomu NamikawaKazuhiro Hanazaki
Apr 29, 2015·Japanese Journal of Radiology·Makiko TakeuchiYoshikazu Morimoto
Jun 26, 2015·BMJ Case Reports·Isha VermaAbhinav Agrawal

❮ Previous
Next ❯


Jul 2, 2021·Case Reports in Surgery·Yuki OkutomiToishiki Rikiyama

❮ Previous
Next ❯

Methods Mentioned

surgical resection

Related Concepts

Related Feeds


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Related Papers

World Journal of Gastroenterology : WJG
Alba RoccoGerardo Nardone
The Israel Medical Association Journal : IMAJ
Stuart A Becker, Nadia Ziv-Sokolovskya
Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
Gajanan D WagholikarVinay K Kapoor
© 2021 Meta ULC. All rights reserved