A giant cord hemangioma with extramedullary hematopoiesis and elevated maternal serum human chorionic gonadotropin: a case report and review of the literature

Diagnostic Pathology
Kieko HaraTakashi Yao

Abstract

A case of prenatally diagnosed, giant cord hemangioma is reported, which was accompanied by the elevation of maternal serum alpha-fetoprotein (MS-AFP) and human chorionic gonadotropin (MS-hCG) levels. A 30-year-old woman without a previous history of gravida or para, presented with intermittent abdominal pain at 26 weeks of gestation. Doppler studies showed the fetus developing heart failure as the tumor grew larger. Caesarian section was performed at 29 weeks of gestation. Macroscopic examination of the placenta revealed a 17.0 × 10.0 × 7.0 cm tumor localized at the placental end of the umbilical cord. Microscopically, the tumor was composed of small arborizing vessels proliferating in the myxoid background, and the tumor cells were positive for AFP by immunohistochemistry. Extramedullary hematopoiesis was seen in the tumor vascular channels. The present case is one of the largest umbilical cord hemangiomas reported in the literature, and the first hemangioma case with MS-hCG elevation, extramedullary hematopoiesis, and positive AFP staining in the cord hemangioma. Its clinical course and detailed pathological findings are presented along with a review of the related literature.

References

May 1, 1990·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·A GhidiniJ C Hobbins
Mar 1, 1989·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·M S Pollack, L M Bound
Nov 1, 1988·Archives of Dermatology·L K GreenT R Burns
Oct 1, 1983·Pediatric Pathology·S A Heifetz, M E Rueda-Pedraza
Mar 1, 1980·Obstetrics and Gynecology·D W Fortune, A G Ostör
May 1, 1994·Acta Obstetricia Et Gynecologica Scandinavica·G Søndergaard
Jan 21, 2000·Fetal Diagnosis and Therapy·M KamitomoT Ikenoue
Mar 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maria Luisa S Sequeira LopezR Ariel Gomez
Jul 23, 2004·Journal of Cutaneous Pathology·Suzana M Vega HarringMotoshige Kudo
Apr 26, 2005·Prenatal Diagnosis·Etty Daniel-SpiegelEliezer Shalev
May 11, 2006·Pathology, Research and Practice·Theodoros VougiouklakisKonstantinos Charalabopoulos
Oct 27, 2006·Pediatric Hematology and Oncology·Neriman SariMünevver Büyükpamukçu
Nov 18, 2006·European Journal of Pediatrics·Giancarlo NatalucciHans Ulrich Bucher
Dec 19, 2006·Taiwanese Journal of Obstetrics & Gynecology·Hung-Pin ChengTsung-Hsien Su
Mar 3, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Vassilis G PapadopoulosGeorge O Decavalas
Aug 4, 2010·Archives of Gynecology and Obstetrics·S SathiyathasanR Hamid
Sep 29, 2012·Fetal and Pediatric Pathology·Suzanne M Jacques, Faisal Qureshi
Jul 3, 2013·International Journal of Surgical Pathology·Shaun ChouAnita Achan
Jul 28, 2013·The American Journal of Surgical Pathology·Jingmei LinElizabeth Montgomery
Oct 24, 2013·Pathology International·Sakda WaraasawapatiMotoshige Kudo
Feb 20, 2014·Histopathology·Oleksandr N KryvenkoLuan D Truong

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Citations

Mar 30, 2020·Abdominal Radiology·Hassan AboughaliaMariam Moshiri

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