A glial blueprint for gliomagenesis

Nature Reviews. Neuroscience
Dylan LaugBenjamin Deneen

Abstract

Gliomas are heterogeneous tumours derived from glial cells and remain the deadliest form of brain cancer. Although the glioma stem cell sits at the apex of the cellular hierarchy, how it produces the vast cellular constituency associated with frank glioma remains poorly defined. We explore glioma tumorigenesis through the lens of glial development, starting with the neurogenic-gliogenic switch and progressing through oligodendrocyte and astrocyte differentiation. Beginning with the factors that influence normal glial linage progression and diversity, a pattern emerges that has useful parallels in the development of glioma and may ultimately provide targetable pathways for much-needed new therapeutics.

References

Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·L das NevesF Godinho
Jul 2, 2003·Development·Hae-Chul Park, Bruce Appel
Jul 5, 2003·Genes & Development·C Claus StoltMichael Wegner
Jun 17, 2004·Journal of Neuropathology and Experimental Neurology·Keith L LigonDavid H Rowitch
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yoh-suke MukouyamaDavid J Anderson
Oct 27, 2007·Neuropathology and Applied Neurobiology·B SchlierfM Wegner
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D CahoyBen A Barres
Feb 9, 2008·Genes & Development·Núria de la IglesiaAzad Bonni
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Feb 17, 2009·Developmental Cell·Masakazu NamihiraKinichi Nakashima
Jul 16, 2009·Current Molecular Medicine·Núria de la IglesiaAzad Bonni
Feb 13, 2010·Neuro-oncology·Hae-Ri SongAnat Erdreich-Epstein
Aug 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Jin ChewVittorio Gallo
Dec 16, 2010·Cancer Cell·Anders I PerssonWilliam A Weiss
Jan 27, 2011·Development·Xiaoqin ZhuAkiko Nishiyama
Feb 10, 2011·Glia·Dolores HambardzumyanAl Charest
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 23, 2011·Annual Review of Neuroscience·Stephen P J FancyDavid H Rowitch
Aug 25, 2011·Nature Reviews. Clinical Oncology·Tony S K Mok
Jun 30, 2012·Science·Hui-Hsin TsaiDavid H Rowitch
Jul 4, 2012·Neurosurgery Clinics of North America·Christopher JacksonMichael Lim

❮ Previous
Next ❯

Citations

Oct 4, 2018·Medical Sciences : Open Access Journal·Ugo TestaElvira Pelosi
Aug 20, 2019·Journal of Cellular and Molecular Medicine·Hao PengQing Liu
Nov 2, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Chengkun YeHongmei Liu
Mar 10, 2020·PLoS Biology·Christine M TaitMarysia Placzek
Apr 7, 2020·The Journal of Clinical Investigation·Asante HatcherJeffrey L Noebels
Jun 9, 2020·International Journal of Cancer. Journal International Du Cancer·Erik JungFrank Winkler
Jul 11, 2020·PloS One·Krishna D SharmaJennifer Yanhua Xie
Sep 21, 2019·Nature Reviews. Neuroscience·Ru-Rong JiMaiken Nedergaard
Jun 4, 2019·Frontiers in Neuroscience·Juan Carlos González-Orozco, Ignacio Camacho-Arroyo
Nov 14, 2019·Nature Neuroscience·Erik JungFrank Winkler
Mar 21, 2020·Frontiers in Oncology·Kholoud Arafa, Marwan Emara
Jul 28, 2019·Cell Communication and Signaling : CCS·Yanfang YangShufang Liang
Nov 30, 2019·Frontiers in Genetics·Noriaki SasaiToru Kondo
Dec 29, 2020·Seminars in Cancer Biology·Md Sahab UddinGhulam Md Ashraf
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayesha Atiq, Ishwar Parhar
Dec 23, 2020·International Journal of Molecular Sciences·Santiago HaaseMaria G Castro
Dec 22, 2020·Carcinogenesis·Kok-Siong ChenLinda J Richards
Feb 23, 2021·Frontiers in Immunology·Min ChaoLiang Wang
Mar 12, 2021·International Journal of Nanomedicine·Yanghao ZhouYuan Cheng
May 14, 2021·Stem Cell Reviews and Reports·Katrien NeyrinckCatherine Verfaillie
Jun 22, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Enrico Brognaro
Oct 16, 2021·Frontiers in Cell and Developmental Biology·Cha LinXinjian Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
xenografts
nucleotide exchange
dissect

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Newsweek
Geoffrey Cowley, Claudia Kalb
Annals of the New York Academy of Sciences
A Prochiantz, M Mallat
Upsala Journal of Medical Sciences
Yiwen Jiang, Lene Uhrbom
© 2022 Meta ULC. All rights reserved