A global assembly line for cyanobactins.

Nature Chemical Biology
Mohamed S DoniaEric W Schmidt

Abstract

More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.

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Citations

Mar 3, 2010·Applied Microbiology and Biotechnology·Kaarina SivonenJouni Jokela
Aug 17, 2010·Journal of the American Chemical Society·Albert A BowersMichael G Acker
Oct 22, 2010·Journal of the American Chemical Society·John A McIntoshEric W Schmidt
Jul 20, 2011·Journal of the American Chemical Society·John A McIntoshEric W Schmidt
Nov 24, 2011·Journal of the American Chemical Society·Ma Diarey B TianeroEric W Schmidt
Mar 10, 2012·Journal of the American Chemical Society·Joel O MelbyDouglas A Mitchell
Mar 31, 2012·Journal of the American Chemical Society·Ying XuPei-Yuan Qian
Jun 13, 2012·Journal of the American Chemical Society·Albert A BowersChristopher T Walsh
Jan 27, 2009·Journal of the American Chemical Society·Jaeheon LeeEric W Schmidt
Mar 10, 2010·Journal of the American Chemical Society·John A McIntoshEric W Schmidt
Jan 12, 2012·Journal of Natural Products·Eric W SchmidtJacques Ravel
Jan 8, 2014·Journal of Natural Products·Cyril PortmannKarl Gademann
Jul 22, 2008·Nature Chemical Biology·Eric W Schmidt
Dec 18, 2009·Nature Chemical Biology·Trent J Oman, Wilfred A van der Donk
Jul 17, 2012·Nature Structural & Molecular Biology·Jesko KoehnkeJames H Naismith
Aug 1, 2009·Natural Product Reports·John A McIntoshEric W Schmidt
Oct 22, 2009·Natural Product Reports·Sean F BradyEric W Schmidt
May 20, 2011·Chemical Communications : Chem Comm·Jason M Crawford, Jon Clardy
Jul 19, 2011·Chemical Communications : Chem Comm·Takayuki KatohHiroaki Suga
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Laura C Wieland BrownMichael A Fischbach
Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mohamed S DoniaEric W Schmidt
Mar 17, 2009·The Journal of Biological Chemistry·Douglas A MitchellJack E Dixon
Jun 5, 2010·The Journal of Biological Chemistry·Christopher T WalshAlbert A Bowers
Aug 29, 2009·Science·Michael A Fischbach, Christopher T Walsh
Dec 17, 2009·Applied and Environmental Microbiology·Niina LeikoskiKaarina Sivonen
Sep 21, 2010·Applied and Environmental Microbiology·Kerstin EngelhardtSergey B Zotchev
Dec 3, 2008·Applied and Environmental Microbiology·Niina LeikoskiKaarina Sivonen
Mar 30, 2011·PloS One·Mohamed S DoniaEric W Schmidt
Oct 22, 2013·Journal of Industrial Microbiology & Biotechnology·Mikhail O Maksimov, A James Link
Oct 11, 2011·Nature Chemical Biology·Roland D KerstenPieter C Dorrestein
Jun 1, 2013·Journal of the American Chemical Society·Kyle L Dunbar, Douglas A Mitchell
Oct 2, 2009·Cellular and Molecular Life Sciences : CMLS·David J CraikNorelle L Daly
Jan 30, 2015·Critical Reviews in Microbiology·Rathinam RajaIsabel S Carvalho
Feb 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ma Diarey TianeroEric W Schmidt
Dec 29, 2015·Current Opinion in Chemical Biology·Debosmita Sardar, Eric W Schmidt
Oct 22, 2015·ACS Chemical Biology·Natalia A JungmannRoderich D Süssmuth
Mar 30, 2012·Current Opinion in Chemical Biology·Hala A IqbalSean F Brady

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