A Glucose/Oxygen-Exhausting Nanoreactor for Starvation- and Hypoxia-Activated Sustainable and Cascade Chemo-Chemodynamic Therapy.

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Yuxin GuoFu-Gen Wu

Abstract

Fenton reaction-mediated chemodynamic therapy (CDT) can kill cancer cells via the conversion of H2 O2 to highly toxic HO•. However, problems such as insufficient H2 O2 levels in the tumor tissue and low Fenton reaction efficiency severely limit the performance of CDT. Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion. The HGTFT nanoreactor can efficiently convert oxygen into HO• for CDT, consume glucose for starvation therapy, and provide a hypoxic environment for TPZ radical-mediated chemotherapy. Besides, it is revealed that the nanoreactor can significantly elevate the intracellular reactive oxygen species content and hypoxia level, decrease the intracellular glutathione content, and release metal ions in the tumors for metal ion interference therapy (also termed "ion-interference therapy" or "metal ion therapy"). Further, the nanoreactor can also increase the tumor's hypoxia lev...Continue Reading

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Citations

Sep 29, 2020·Advanced Healthcare Materials·Huige ZhouChunying Chen
Oct 29, 2020·Chemical Society Reviews·Jiajie ChenJianlin Shi
Apr 17, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ya-Xuan ZhuFu-Gen Wu
Mar 11, 2021·Biomaterials Science·Peng LiuWenhu Zhou
May 12, 2021·ACS Nano·Xiaotong ChengFu-Gen Wu
May 28, 2021·Research : a Science Partner Journal·Xiulin YiFu-Gen Wu
Jun 30, 2021·Journal of Nanobiotechnology·Jingqi XinFeifei An
Jul 20, 2021·ACS Applied Materials & Interfaces·Dan MuBing Zhang
Jul 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sheng-Yan YinJishan Li
Sep 14, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Qian WangJingcheng Hao
Sep 24, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yunkai KouXiuwen Zheng
Nov 17, 2021·ACS Applied Materials & Interfaces·Pengli GaoMin Zheng
Nov 4, 2021·Advanced Healthcare Materials·Zihao Wang, Fu-Gen Wu

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