A glutamate-dopamine interaction in the persistent enhanced response to amphetamine in nucleus accumbens core but not shell following a single restraint stress

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Alejandra M PacchioniL M Cancela

Abstract

The administration of psychostimulant drugs or stress can elicit a sensitized response to the stimulating and reinforcing properties of the drug. We previously demonstrated that a single restraint stress session enhanced d-amphetamine (d-AMPH)-induced locomotion the day after the stress session, which lasted up to 8 days. The present experiments were designed to identify the contribution of major dopamine (DA) brain areas in the short- and long-lasting enhancement of d-AMPH-induced locomotion following a single stress, and to test the involvement of N-methyl-D-aspartate (NMDA) receptors in that phenomena. To achieve our goal, 24 h and 8 days after a 2-h restraint stress session either with or without a NMDA receptor blockade, we measured locomotor activity and DA overflow in nucleus accumbens (NAcc) core and shell and caudate putamen (CPu) following a d-AMPH injection (0.5 mg/kg i.p.). The stimulant effect of d-AMPH on DA overflow was enhanced in all nuclei at 24 h after a single stress, while at 8 days the enhanced responsiveness was maintained only in the NAcc core. When the rats were administered with MK-801 (0.1 mg/kg i.p.) 30 min before restraint stress, the d-AMPH-induced enhancement on locomotor activity and DA neurotran...Continue Reading

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Citations

Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Klaus A MiczekHerbert E Covington
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chun-hui Chang, Anthony A Grace
Mar 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ornella ValentiAnthony A Grace
Dec 29, 2013·Psychopharmacology·Andrew R Burke, Klaus A Miczek
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May 20, 2015·Pharmacology, Biochemistry, and Behavior·S Montagud-RomeroM Rodríguez-Arias
Apr 13, 2010·Biochemical and Biophysical Research Communications·Tie-feng ShiMan-ying Xu
Aug 14, 2012·The European Journal of Neuroscience·Maria A EsparzaLiliana M Cancela
Nov 29, 2014·Addiction Biology·Bethania Mongi-BragatoLiliana M Cancela
Oct 3, 2013·Pharmacology, Biochemistry, and Behavior·Darakhshan Jabeen HaleemMuhammad Abdul Haleem
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Jan 10, 2019·Frontiers in Psychology·Angélica Torres-BerrioMauricio O Nava-Mesa
Jun 26, 2021·Neurobiology of Stress·Daiana RigoniFlavia Bollati

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