A gonadotropin-releasing hormone agonist for the prevention of docetaxel-induced gonadal damage

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
Ilhae ParkNak Woo Lee

Abstract

This study aimed to evaluate the protective effect of a gonadotropin-releasing hormone (GnRH) agonist against docetaxel-induced gonadotoxicity in a mouse model. Forty mice (female B6, 6-8 weeks old, weighing 16-18 g) were divided randomly into four groups. Groups 1 and 2 were treated with a single intraperitoneal dose of 0.1 mL normal saline; Groups 3 and 4 received 30 mg/kg docetaxel. Groups 2 and 4 were pre-treated with a subcutaneous injection of 0.3 mg leuprolide acetate, 2 weeks before the administration of docetaxel. The ovaries were removed 6 weeks after docetaxel or saline injection. Total follicle number decreased in Group 3 compared to Group 1. There was a significant difference between the Groups 3 and 4 in the total follicle number. Many ovarian follicles were stained for Ki-67 in Groups 1, 2, and 4; however, in Group 3, only a small number were stained and destruction of the ovarian structure was observed. There was no immunohistochemistry staining with γ-H2AX in Groups 1, 2, and 4. However, γ-H2AX staining of the primordial follicles was observed in Group 3. GnRH agonists may protect ovarian follicles from docetaxel-induced ovarian damage considering the total follicle number, follicle proliferation, and double-st...Continue Reading

References

Nov 29, 1973·The New England Journal of Medicine·G L WarneF I Martin
May 3, 2003·Cell Death and Differentiation·J L Tilly, R N Kolesnick
Jun 7, 2003·Endocrine-related Cancer·G EmonsC Verschraegen
Apr 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kutluk OktayZev Rosenwaks
Aug 3, 2006·The Journal of Clinical Endocrinology and Metabolism·Kutluk OktayHeejung Bang
May 22, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ann PartridgeEric Winer
Feb 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie R Schover
May 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernd GerberUNKNOWN German Breast Group Investigators
Jan 11, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela N MunsterSusan E Minton
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn J Ruddy, Ann H Partridge
Dec 25, 2012·Obstetrics and Gynecology·Eman A ElgindyAhmed M Abou-Setta
May 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alison W LorenUNKNOWN American Society of Clinical Oncology
Mar 5, 2015·The New England Journal of Medicine·Halle C F MooreUNKNOWN POEMS/S0230 Investigators
May 6, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A S CoatesUNKNOWN Panel Members
Jan 6, 2016·BMC Medicine·Matteo LambertiniPaola Anserini

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Citations

Dec 6, 2019·International Journal of Molecular Sciences·Paola ScaruffiLucia Del Mastro

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