A gp130-Src-YAP module links inflammation to epithelial regeneration

Nature
Koji TaniguchiMichael Karin

Abstract

Inflammation promotes regeneration of injured tissues through poorly understood mechanisms, some of which involve interleukin (IL)-6 family members, the expression of which is elevated in many diseases including inflammatory bowel diseases and colorectal cancer. Here we show in mice and human cells that gp130, a co-receptor for IL-6 cytokines, triggers activation of YAP and Notch, transcriptional regulators that control tissue growth and regeneration, independently of the gp130 effector STAT3. Through YAP and Notch, intestinal gp130 signalling stimulates epithelial cell proliferation, causes aberrant differentiation and confers resistance to mucosal erosion. gp130 associates with the related tyrosine kinases Src and Yes, which are activated on receptor engagement to phosphorylate YAP and induce its stabilization and nuclear translocation. This signalling module is strongly activated upon mucosal injury to promote healing and maintain barrier function.

References

Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·R RazD E Levy
Mar 15, 2005·The Journal of Clinical Investigation·Kyoko KatakuraEyal Raz
Jun 17, 2005·Nature·Silvia FreSpyros Artavanis-Tsakonas
Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Sarah J Bray
May 26, 2007·Nature Reviews. Immunology·Akihiko YoshimuraMasato Kubo
Nov 6, 2007·Current Biology : CB·Fernando D CamargoThijn R Brummelkamp
Apr 11, 2008·The Journal of Investigative Dermatology·Hsiao-Tang HuLi-Wha Wu
Jul 5, 2008·Nature Protocols·Claudia Mitchell, Holger Willenbring
Jul 25, 2008·Nature·Ruslan Medzhitov
Nov 22, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryuichi OkamotoMamoru Watanabe
Jun 13, 2009·Current Pharmaceutical Design·Stefan Rose-JohnJürgen Scheller
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Apr 23, 2010·International Immunology·Tadamitsu Kishimoto
May 18, 2010·Nature Medicine·Sung Hee LeeEyal Raz
Jul 9, 2010·Journal of Leukocyte Biology·Tracy Putoczki, Matthias Ernst
Jun 22, 2011·The Journal of Experimental Medicine·Camilla PilatiJessica Zucman-Rossi
Jul 21, 2011·Nature Immunology·Yinon Ben-Neriah, Michael Karin
Aug 10, 2011·The Journal of Experimental Medicine·Monica GumaMichael Karin
Sep 14, 2011·Annual Review of Pharmacology and Toxicology·Toshio TanakaTadamitsu Kishimoto
Nov 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dawang ZhouJoseph Avruch
Mar 30, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Joëlle A BaddourPanagiotis A Tsonis
May 19, 2012·Cytokine & Growth Factor Reviews·Christoph GarbersJürgen Scheller
Feb 23, 2013·Genes & Development·Fa-Xing Yu, Kun-Liang Guan
Sep 17, 2013·Developmental Cell·Ryouhei TsutsumiMasanori Hatakeyama

❮ Previous
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Citations

Jan 24, 2016·Journal of Crohn's & Colitis·D Ortiz-MasiáM D Barrachina
Jul 29, 2015·The Journal of Cell Biology·Nam-Gyun Kim, Barry M Gumbiner
Feb 13, 2016·Journal of Hepatology·Dirk Schmidt-Arras, Stefan Rose-John
Jan 12, 2016·Current Opinion in Rheumatology·Xiao LiuSimon A Jones
Jul 4, 2015·Journal of Gastroenterology·Ryuichi Okamoto, Mamoru Watanabe
Dec 19, 2015·Cerebral Cortex·Zhihui HuangWen-Cheng Xiong
Oct 16, 2015·Biochemistry·Kun ZhangWei Hong
Jun 18, 2016·Molecular & Cellular Oncology·Alex Gregorieff, Jeffrey L Wrana
Mar 15, 2016·Nature Reviews. Genetics·Andrew P FeinbergAnita Göndör
Jun 9, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sumera RizviGregory J Gores
May 6, 2015·Translational Stroke Research·Xiao-Yi Xiong, Qing-Wu Yang
Mar 2, 2016·The Journal of Clinical Investigation·Dongjun LeeDavid T Scadden
Jul 21, 2015·Cytokine & Growth Factor Reviews·Camilla Pilati, Jessica Zucman-Rossi
Jul 21, 2015·Cytokine & Growth Factor Reviews·Fred Schaper, Stefan Rose-John
Jun 6, 2015·Trends in Cell Biology·Carsten Gram HansenKun-Liang Guan
Apr 22, 2015·Nature Immunology·Christopher A Hunter, Simon A Jones
May 14, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ahmed ElbediwyBarry J Thompson
May 26, 2016·Nature Reviews. Molecular Cell Biology·Min LuXin Lu
Jun 9, 2016·Trends in Cell Biology·Shuguo Sun, Kenneth D Irvine
Jun 15, 2016·Cancer Cell·Francesca ZanconatoStefano Piccolo
Jun 18, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carolin PloegerStephanie Roessler
Aug 10, 2016·The Journal of Experimental Medicine·Lakmali AtapattuPeter W Janes
Oct 22, 2016·Current Opinion in Cell Biology·Marina Pesic, Florian R Greten
Aug 25, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Guo ZuXiaofeng Tian
Oct 25, 2016·Immunological Investigations·Kepeng Wang, Anthony T Vella
Oct 22, 2016·Current Opinion in Cell Biology·Iván M Moya, Georg Halder
Apr 27, 2016·American Journal of Respiratory Cell and Molecular Biology·Anna A BirukovaKonstantin G Birukov
Nov 11, 2016·Probiotics and Antimicrobial Proteins·Violeta LorénJordi Espadaler
Oct 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juri BergmannDirk Schmidt-Arras
Dec 9, 2016·Cell Death & Disease·Chiara Fazio, Luigi Ricciardiello
Apr 19, 2017·International Journal of Molecular Sciences·Yuji NakayamaNaoto Yamaguchi
Dec 14, 2016·Annual Review of Pathology·Robert P Schleimer
Dec 22, 2016·Nature Communications·Ines JericManuela Baccarini
Jun 21, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Juliane LokauChristoph Garbers

❮ Previous
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