A granulomatous reaction to Avitene mimicking recurrence of a medulloblastoma. Case report

Journal of Neurosurgery
Brian A O'ShaughnessyTadanori Tomita

Abstract

Microfibrillar collagen hemostat (MCH), also known by its trade name Avitene, is commonly used to control hemorrhage during neurosurgery. Among the documented complications associated with this agent, a granulomatous foreign body reaction is rare, having been described in the central nervous system in only one previous clinical report. In the present study, the authors report the case of a 3-year-old boy who presented with a lesion which appeared to be the recurrence of a tumor 2 months after he had undergone gross-total resection for a medulloblastoma. The patient underwent resection of the presumed recurrent tumor, but histopathological analysis of the specimen revealed a granulomatous foreign body reaction to MCH and no tumor recurrence. In addition to describing the case, the authors review the surgical literature on foreign body reactions to MCH.

References

Jan 1, 1987·Haemostasis·M McClureF Robicsek
Jan 1, 1974·Haemostasis·R G Mason, M S Read
Jul 1, 1984·Plastic and Reconstructive Surgery·H S Sturim
Sep 26, 2002·Journal of Neurosurgery·Stephen HentschelJohn Kestle

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Citations

Aug 28, 2012·Case Reports in Surgery·Mario GanauLeonello Tacconi
Nov 4, 2015·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·V A KhachatryanV P Ivanov
Jun 14, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Giuseppe Roberto GiammalvaRosario Maugeri

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