A gross morphologic, histologic, hematologic, and blood chemistry study of adult and neonatal mice chronically exposed to high magnetic fields

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
M OsbakkenP Taczanowsky

Abstract

Six sets of Charles River CD-1 mice (3 sets of adults and 3 sets of offspring: 156 mice total) were raised for varying times (360 h over 1 month to 624 h over 3 months) in a 1.89-T magnetic field. Each set was divided into 3 groups: control group raised in the animal facility (Control); control group raised in the magnet room but not in the magnet (Magnet-Controls); experimental group raised in the magnet (Magnet). At the end of each predefined exposure period, the mice were euthanized and studied. Body and organ weights were lower in 3 of 6 sets in the Magnet groups when compared to Control groups, but they were not significantly different from age matched, sex matched Magnet-Controls. This seems to indicate that the decreased growth of mice was due to the laboratory environment surrounding the magnet, when compared to the animal facility environment, rather than to magnetic field effects. No consistent differences were found in gross and microscopic morphology, hematocrit and white blood cell counts, plasma creatine phosphokinase, lactic dehydrogenase, cholesterol, triglyceride, or protein concentrations in Magnet groups compared to the two control groups.

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Citations

Jan 1, 1991·Journal of Magnetic Resonance Imaging : JMRI·F G Shellock, E Kanal
Nov 1, 1993·Reproductive Toxicology·R L BrentD A Beckman
Sep 12, 2015·Environmental Science and Pollution Research International·Miryam ElferchichiKaren Lambert
Sep 22, 2009·Archives of Medical Research·Dilek Ulker CakirNuriye Mete
Jan 1, 1987·Magnetic Resonance Imaging·R E GangarosaR W Genberg
Feb 24, 2006·Radiation Research·Angela M Sommer, Alexander Lerchl
Aug 10, 2000·Journal of Magnetic Resonance Imaging : JMRI·R L MaginF Dunn
Mar 6, 2004·Nihon Hoshasen Gijutsu Gakkai zasshi·Tosiaki Miyati
May 21, 2021·Saudi Journal of Biological Sciences·Imam HasanMohammad Rafiqul Islam

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