A group of five parameters as a new biological marker on F344/N rats

Archives of Gerontology and Geriatrics
S TanakaTamio Ohno

Abstract

The National Institute for Longevity Sciences (NILS) established an aging farm (A/F) for producing aging/aged laboratory rodents at the Experimental Animal Facility Wing under the NILS A/F Guide planned by the Laboratory Animal Research Facilities (LARF). Five parameters, the average life span, the number of days of 75, 50, and 25% survival points, and average of the top 10 longest life span among laboratory strains of rodents at NILS-A/F, were reproducible for F344/N rats specifically by strain and sex under the LARF A/F guide. These five parameters may serve as an effective and practical biological marker, especially in aging science including longevity science, to evaluate characteristics of strains of laboratory rodents. The five parameters can identify clear substrain differences between F344/N and F344/Du and breeder differences between F344/DuCrj and F344/DuCrl.

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Citations

Feb 7, 2004·Archives of Gerontology and Geriatrics·Shin TanakaTamio Ohno
Feb 7, 2004·Archives of Gerontology and Geriatrics·Shin TanakaYoshitake Itoh
May 31, 2013·Reproductive Biology·Kazutoshi NishijimaShuji Kitajima
Apr 27, 2007·Experimental Animals·Keiko SoneShin Tanaka
Jun 17, 2003·Experimental Animals·Satoshi Fukuda, Haruzo Iida
Apr 17, 2007·Archives of Oral Biology·Kazutoshi NishijimaShin Tanaka
Aug 4, 2018·Journal of Anatomy·Kazutoshi NishijimaShin Tanaka
Jul 11, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Robin C May
Jul 20, 2007·American Journal of Physiology. Renal Physiology·Mohammad AsgharMustafa F Lokhandwala

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