A group of non-serotonergic cells is CO2-stimulated in the medullary raphé

Neuroscience
Kimberly E Iceman, Michael B Harris

Abstract

Serotonin/substance P synthesizing cells in the raphé nuclei of the brain are candidates for designation as central chemoreceptors that are stimulated by CO2/pH. We have previously demonstrated that these neurons are CO2-stimulated in situ. Evidence also suggests that CO2-inhibited raphé neurons recorded in vitro and in situ synthesize GABA. Unknown is whether there are other types of chemosensitive cells in the raphé. Here, we showed that a previously unrecognized pool of raphé neurons also exhibit chemosensitivity, and that they are not serotonergic. We used extracellular recording of individual raphé neurons in the unanesthetized juvenile rat in situ perfused decerebrate brainstem preparation to assess chemosensitivity of raphé neurons. Subsequent juxtacellular labeling of individually recorded cells, and immunohistochemistry for the serotonin synthesizing enzyme tryptophan hydroxylase and for neurokinin-1 receptor (NK1R; the receptor for substance P) indicated a group of CO2-stimulated cells that are not serotonergic, but express NK1R and are closely apposed to surrounding serotonergic cells. CO2-stimulated 5-HT and non-5-HT cells constitute distinct groups that have different firing characteristics and hypercapnic sensitiv...Continue Reading

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Sep 21, 2013·Journal of Neurophysiology·Kimberly E IcemanMichael B Harris

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Citations

Aug 5, 2014·Respiratory Physiology & Neurobiology·Kimberly E IcemanMichael B Harris
Jul 28, 2015·Autonomic Neuroscience : Basic & Clinical·S L JohansenM B Harris
Jul 6, 2020·The Journal of Physiology·Karine C FlorDaniel B Zoccal
Feb 20, 2015·Journal of Neurophysiology·Cory A MasseyGeorge B Richerson
Sep 12, 2020·Pflügers Archiv : European journal of physiology·Isabela P LeirãoGlauber S F da Silva
Jan 21, 2015·Physiological Reports·Bowen DempseySimon McMullan

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Kimberly E IcemanMichael B Harris
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