A gut feeling about the ketogenic diet in epilepsy.

Epilepsy Research
Quentin J Pittman

Abstract

The ketogenic diet has been used to treat intractable epilepsy for many years, yet the mechanism(s) underlying its effectiveness have not been completely elucidated. However, emerging evidence indicates that the ketogenic diet may correct or otherwise alter a 'dystopic' gut microbiota that exhibits altered fecal microbial composition compared to healthy individuals. Recent studies in animal seizure models also reveal altered gut microbiome, as well as changes in the composition of the microbiota after ingestion of a ketogenic diet. The effectiveness of the ketogenic diet in these animal models appears to be absolutely dependent upon the presence of gut microbiota. Further evidence suggests that effectiveness of the ketogenic diet in controlling seizures may be reliant upon the ability of specific bacterial populations to alter gamma glutamylation of amino acids and thus alter their uptake into the central nervous system. These studies suggest new directions for research in patients with epilepsy.

Citations

Mar 26, 2021·Seizure : the Journal of the British Epilepsy Association·Diana Marcela Mejía-GranadosPasquale Striano
Jul 3, 2021·Nutrients·Ladislav PilařIvana Tichá
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Katarzyna SocałaPiotr Wlaź

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nestlé Nutrition Workshop Series. Clinical & Performance Programme
J M Freeman
Canadian Medical Association Journal
A D B
Handbook of Clinical Neurology
Roberto H Caraballo, Eileen Vining
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Jian-Xiang LiaoDe-Zhi Cao
Archives of Disease in Childhood
R W Ellis
© 2021 Meta ULC. All rights reserved