A gut feeling for joint inflammation - using coeliac disease to understand rheumatoid arthritis

Trends in Immunology
Øyvind Molberg, Ludvig M Sollid

Abstract

Major advances have been made in the molecular understanding of coeliac disease, initiated by the identification of intestinal gluten-reactive T cells. It is now clear that this common intestinal disorder, which is precipitated by the ingestion of wheat gluten, is mediated by DQ2-restricted T cells specific for gluten peptides modified by transglutaminase 2, the same enzyme that is targeted by disease-specific autoantibodies. Interestingly, many of the important features identified in coeliac disease, including HLA association, target organ T-cell infiltration, disease-specific autoantibodies and the distinct targeting of in vivo modified antigens, are also present in rheumatoid arthritis. The experiences from coeliac disease should therefore help identify disease-relevant T-cell epitopes in rheumatoid arthritis.

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M LondeiM Feldmann
Feb 14, 1998·The Journal of Clinical Investigation·G A SchellekensW J van Venrooij
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·B L KotzinJ Kappler
Feb 24, 2001·Arthritis and Rheumatism·C C Reparon-SchuijtC L Verweij
Mar 6, 2002·The Journal of Experimental Medicine·L Willemijn VaderFrits Koning
Jun 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Johan BäcklundRikard Holmdahl
Sep 5, 2002·Nature Reviews. Immunology·Ludvig M Sollid
Sep 28, 2002·Science·Lu ShanChaitan Khosla
Apr 11, 2003·Arthritis and Rheumatism·Damini JawaheerUNKNOWN North American Rheumatoid Arthritis Consortium
May 16, 2003·Nature·Gary S Firestein
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Veronika GrohThomas Spies
Oct 9, 2003·Current Rheumatology Reports·Sean R BennettBrian L Kotzin
Oct 28, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Erik R VossenaarGer J M Pruijn
Jan 30, 2004·The Journal of Biological Chemistry·Burkhard FleckensteinLudvig M Sollid
Feb 11, 2004·Joint, Bone, Spine : Revue Du Rhumatisme·Olivier Meyer
Mar 17, 2004·Annals of the Rheumatic Diseases·P J UtzW H Robinson
Mar 17, 2004·Annals of the Rheumatic Diseases·E R VossenaarW J van Venrooij
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chu-Young KimLudvig M Sollid
Apr 16, 2004·The American Journal of the Medical Sciences·Edward F RosloniecAndrew H Kang
Sep 11, 2004·Immunity·Sophie HüeSophie Caillat-Zucman
Oct 14, 2004·Annals of the Rheumatic Diseases·S M CartyA J Silman
Nov 6, 2004·Arthritis and Rheumatism·Erik R VossenaarPaul P Tak
Jan 5, 2005·Biochemical and Biophysical Research Communications·Makiko Nakayama-HamadaKazuhiko Yamamoto
Apr 16, 2005·European Journal of Immunology·Harald BurkhardtRikard Holmdahl
Jul 15, 2005·Annals of the New York Academy of Sciences·Giuseppina MerliniPaola Migliorini
Sep 29, 2005·Rheumatology·A J W ZendmanG J M Pruijn
Oct 11, 2005·Current Opinion in Immunology·Ludvig M Sollid, Bana Jabri
Nov 16, 2005·Gastroenterology·Luigi MaiuriMarco Londei

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Citations

Apr 24, 2009·The Journal of Biological Chemistry·Evgeny A ZemskovAlexey M Belkin
Aug 4, 2009·Human Molecular Genetics·Marieke J H CoenenAlexandra Zhernakova
Nov 16, 2011·International Journal of Food Sciences and Nutrition·Matthew Metzgar
Jun 1, 2008·Expert Opinion on Medical Diagnostics·Aristo Vojdani
Apr 2, 2014·Autoimmune Diseases·Aristo Vojdani
Aug 27, 2016·Amino Acids·Daniel Aeschlimann, Vera Knäuper
Dec 17, 2008·Annals of the New York Academy of Sciences·Walther J van VenrooijGer J M Pruijn
Mar 16, 2011·Journal of Internal Medicine·J Gutierrez-AchuryC Wijmenga
Jan 10, 2020·Autoimmunity Reviews·Aristo VojdaniElroy Vojdani

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