A H2O2 self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy.

Chemical Science
Shichao ZhangXiaochen Dong

Abstract

Chemodynamic therapy (CDT), employing Fenton or Fenton-like catalysts to convert hydrogen peroxide (H2O2) into toxic hydroxyl radicals (˙OH) to kill cancer cells, holds high promise in tumor therapy due to its high selectivity. However, the anticancer efficacy is unsatisfactory owing to the limited concentration of endogenous H2O2. Herein, thermal responsive nanoparticles with H2O2 self-sufficiency are fabricated by utilizing organic phase change materials (PCMs) to encapsulate iron-gallic acid nanoparticles (Fe-GA) and ultra-small CaO2. PCMs, acting as the gatekeeper, could be melted down by the hyperthermia effect of Fe-GA under laser irradiation with a burst release of Fe-GA and CaO2. The acidic tumor microenvironment would further trigger CaO2 to generate a large amount of H2O2 and Ca2+. The self-supplied H2O2 would be converted into ˙OH by participating in the Fenton reaction with Fe-GA. Meanwhile, in situ generation of Ca2+ could cause mitochondrial damage and lead to apoptosis of tumor cells. With efficient tumor accumulation illustrated in in vivo photoacoustic imaging, Fe-GA/CaO2@PCM demonstrated a superior in vivo tumor-suppressive effect without inducing systemic toxicity. The study presents a unique domino effect ap...Continue Reading

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Citations

Mar 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chen LiangXiaochen Dong
Apr 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei Feng, Yu Chen
Jun 10, 2020·Chemical Communications : Chem Comm·Eunbin Hwang, Hyo Sung Jung
Nov 14, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Junlie YaoAiguo Wu
Sep 29, 2020·Biomaterials Science·Chuanchuan HeGuangya Xiang
Jan 14, 2021·Advanced Science·Hui HuYuehua Li
Mar 6, 2021·Bioactive Materials·Jin HePeng Huang
Apr 14, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuheng WangZhishen Ge
May 9, 2021·Colloids and Surfaces. B, Biointerfaces·Marhaba MamatSong Shen
May 15, 2021·Advanced Materials·Sheng WangXiaoyuan Chen
Nov 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinyi LvXiaochen Dong

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Methods Mentioned

BETA
scanning
dynamic light scattering
electron paramagnetic resonance
fluorescence imaging
xenograft
fluorescence microscopy

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