A handheld microscope integrating photoacoustic microscopy and optical coherence tomography

Biomedical Optics Express
Wei QinLei Xi

Abstract

The combination of optical resolution photoacoustic microscopy (ORPAM) and optical coherence tomography (OCT) is capable of providing complementary imaging contrasts. Unfortunately, the miniaturization of ORPAM remains a major challenge in the development of a handheld dual-modality imaging microscope with OCT. Here, we report the design and evaluation of an integrated ORPAM and OCT imaging probe using a two-dimensional MEMS (micro-electro-mechanical-system)-based optical scanner. This microscope, weighting 35.4 g, has an ultracompact size of 65×30×18 mm3, and an effective imaging area of 2×2 mm2. The experimental lateral resolutions are 3.7 μm (ORPAM) and 5.6 μm (OCT), and the axial resolutions are measured as 120 μm (ORPAM) and 7.3 μm (OCT). Besides phantom and animal experiments, we carried out oral imaging of a healthy volunteer to show the clinical feasibility of this technique.

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Citations

Nov 14, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·B HindelangU Darsow
Apr 17, 2019·Journal of Biophotonics·Qian ChenLei Xi
May 14, 2020·Science China. Life Sciences·Myeongsu Seong, Sung-Liang Chen
Feb 9, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mengyang Liu, Wolfgang Drexler
Dec 11, 2020·Experimental Biology and Medicine·Arash Dadkhah, Shuliang Jiao
Mar 18, 2021·Journal of Biophotonics·Yihao DuanKedi Xiong
Apr 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jeongwoo ParkChulhong Kim

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