A haplotype at the UCP1 gene locus contributes to genetic risk for type 2 diabetes in Asian Indians (CURES-72).

Metabolic Syndrome and Related Disorders
Karani S VimaleswaranViswanathan Mohan

Abstract

The gene encoding for uncoupling protein-1 (UCP1) is considered to be a candidate gene for type 2 diabetes because of its role in thermogenesis and energy expenditure. The objective of the study was to examine whether genetic variations in the UCP1 gene are associated with type 2 diabetes and its related traits in Asian Indians. The study subjects, 810 type 2 diabetic subjects and 990 normal glucose tolerant (NGT) subjects, were chosen from the Chennai Urban Rural Epidemiological Study (CURES), an ongoing population-based study in southern India. The polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Linkage disequilibrium (LD) was estimated from the estimates of haplotypic frequencies. The three polymorphisms, namely -3826A-->G, an A-->C transition in the 5'-untranslated region (UTR) and Met229Leu, were not associated with type 2 diabetes. However, the frequency of the A-C-Met (-3826A-->G-5'UTR A-->C-Met229Leu) haplotype was significantly higher among the type 2 diabetic subjects (2.67%) compared with the NGT subjects (1.45%, P < 0.01). The odds ratio for type 2 diabetes for the individuals carrying the haplotype A-C-Met was 1.82 (95% confidence interval...Continue Reading

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Citations

Jun 9, 2016·Nutrition & Metabolism·Karani S VimaleswaranVenkatesan Radha
Jul 14, 2012·Arquivos brasileiros de endocrinologia e metabologia·Letícia de Almeida BrondaniDaisy Crispim
May 27, 2020·Molecular Medicine·Anna E PravednikovaYulii V Shidlovskii
Nov 22, 2018·BMC Medical Genetics·Shahanas ChathothAmein Al Ali

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Methods Mentioned

BETA
electrophoresis
genotyping

Software Mentioned

Statistical Package for Social Sciences
Arlequin
HAPLOPOP
CURES

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