A haplotype of CYP2C9 associated with warfarin sensitivity in mechanical heart valve replacement patients.

British Journal of Clinical Pharmacology
Su-Jun LeeJae-Gook Shin

Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * CYP2C9 single nucleotide polymorphisms (SNPs) are important in safe and effective oral anticoagulation with warfarin use. * Although CYP2C9*2 and *3 are important genetic factors for the warfarin dose, one of the CYP2C9 SNPs, IVS-65G>C, has been suggested to be associated with warfarin sensitivity. However, as of yet, there has been no explanation about the possible mechanism and linkage analysis. WHAT THIS PAPER ADDS * New information on CYP2C9 SNPs and their occurrences in common haplotype structures in healthy unrelated Koreans and in individuals who require low warfarin dose after mechanical heart valve replacements (MHVRs) were studied. * Additional evidence showed that an Asian dominant haplotype consisting of -1565C>T, -1188T>C, IVS3+197G>A, IVS3-334C>T, IVS3-65G>C, IVS4-115A>G and IVS5-73A>G could be associated with a low warfarin maintenance dose in mechanical heart valve replacement (MHVR) patients. AIMS The objectives of this study were to determine the distribution of CYP2C9 variants in Koreans and investigate their association with warfarin dose requirements in patients who received MHVRs. METHODS All nine exons, intron-exon junction, and promoter region of CYP2C9 were amp...Continue Reading

References

Dec 1, 1994·Pharmacogenetics·J A Goldstein, S M de Morais
Jan 1, 1996·Methods in Enzymology·J O Miners, D J Birkett
Aug 1, 1996·Pharmacogenetics·T H Sullivan-KloseJ A Goldstein
Nov 14, 1997·Pharmacogenetics·K NasuT Ishizaki
Apr 12, 2001·British Journal of Clinical Pharmacology·Y R YoonJ G Shin
Oct 27, 2001·British Journal of Clinical Pharmacology·M G ScordoM Ingelman-Sundberg
Apr 3, 2002·JAMA : the Journal of the American Medical Association·Mitchell K HigashiAllan E Rettie
May 9, 2002·Drug Metabolism Reviews·Slobodan Rendic
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Jul 31, 2004·Pharmacogenetics·Joyce BlaisdellJoyce A Goldstein
Aug 4, 2004·Clinical Pharmacology and Therapeutics·Aurel C AllabiUmit Yasar
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler
Jan 18, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Herng-Der ChernChun-Wen Cheng
Jun 22, 2006·Pharmacogenetics and Genomics·Keiko MaekawaJun-ichi Sawada
Aug 2, 2007·Therapeutic Drug Monitoring·Sang Seop LeeJae-Gook Shin
Aug 6, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ting-Liang WangSusan Tai

❮ Previous
Next ❯

Citations

Feb 1, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Danxin WangJulie A Johnson
Jan 30, 2013·Drug Metabolism and Pharmacokinetics·Su-Jun LeeJae-Gook Shin
Aug 13, 2013·Joint, Bone, Spine : Revue Du Rhumatisme·Rebecca L RobertsTony R Merriman
Dec 15, 2010·British Journal of Clinical Pharmacology·Yoon K LokeJames M Ritter
Jun 9, 2014·Thrombosis Research·Tejasvita GaikwadShrimati Shetty
Feb 22, 2012·Journal of Neurosciences in Rural Practice·Sandeep MohindraAmanjit Bal
Jul 3, 2021·Clinical Pharmacology and Therapeutics·Mustafa Adnan MalkiEwan R Pearson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.