A hard-soft microfluidic-based biosensor flow cell for SPR imaging application

Biosensors & Bioelectronics
Changchun LiuH Li

Abstract

An ideal microfluidic-based biosensor flow cell should have not only a "soft" interface for high strength sealing with biosensing chips, but also "hard" macro-to-micro interface for tubing connection. Since these properties are exclusive of each other, no one material can provide the advantages of both. In this paper, we explore the application of a SiO(2) thin film, deposited by plasma-enhanced chemical vapor deposition (PECVD) technology, as an intermediate layer for irreversibly adhering polydimethylsiloxane (PDMS) to plastic substrate, and develop a hard-soft, compact, robust microfluidic-based biosensor flow cell for the multi-array immunoassay application of surface plasmon resonance (SPR) imaging. This hard-soft biosensor flow cell consists of one rigid, computer numerically controlled (CNC)-machined poly(methyl methacrylate) (PMMA) base coated with a 200 nm thick SiO(2) thin film, and one soft PDMS microfluidic layer. This novel microfluidic-based biosensor flow cell does not only keep the original advantage of conventional PDMS-based biosensor flow cell such as the intrinsically soft interface, easy-to-fabrication, and low cost, but also has a rigid, robust, easy-to-use interface to tubing connection and can be operate...Continue Reading

Citations

Oct 28, 2011·ACS Applied Materials & Interfaces·Ram P GandhiramanDavid E Williams
Jan 19, 2012·Bioanalysis·Thorsten Verch, Ray Bakhtiar
Sep 7, 2013·The Review of Scientific Instruments·L L ZhangD F Cui
Mar 31, 2015·Journal of Laboratory Automation·Yung-Shin Sun
Jan 25, 2014·Scientific Reports·Peyman JahanshahiFaisal Rafiq Mahamd Adikan
Jun 5, 2020·Micromachines·Carlos RuizChangchun Liu
Mar 30, 2011·Lab on a Chip·Changchun LiuHaim H Bau
Jun 2, 2015··Y. NazirizadehM. Gerken

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