A head mounted device stimulator for optogenetic retinal prosthesis.
Abstract
Our main objective is to demonstrate that compact high radiance gallium nitride displays can be used with conventional virtual reality optics to stimulate an optogenetic retina. Hence, we aim to introduce a non-invasive approach to restore vision for people with conditions such as retinitis pigmentosa where there is a remaining viable communication link between the retina and the visual cortex. We design and implement the headset using a high-density µLED matrix, Raspberry Pi, microcontroller from NXP and virtual reality lens. Then, a test platform is developed to evaluate the performance of the headset and the optical system. Furthermore, image simplification algorithms are used to simplify the scene to be sent to the retina. Moreover, in vivo evaluation of the genetically modified retina response at different light intensity is discussed to prove the reliability of the proposed system. We demonstrate that in keeping with regulatory guidance, the headset displays need to limit their luminance to 90 kcd m-2. We demonstrate an optical system with 5.75% efficiency which allows for 0.16 mW mm-2 irradiance on the retina within the regulatory guidance, but which is capable of an average peak irradiance of 1.35 mW mm-2. As this is lo...Continue Reading
References
Biophysical Properties of Optogenetic Tools and Their Application for Vision Restoration Approaches.
A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction
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