A headlight on liquid biopsies: a challenging tool for breast cancer management

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Daniela MassihniaAntonio Russo

Abstract

Breast cancer is the most frequent carcinoma and second most common cause of cancer-related mortality in postmenopausal women. The acquisition of somatic mutations represents the main mechanism through which cancer cells overcome physiological cellular signaling pathways (e.g., PI3K/Akt/mTOR, PTEN, TP53). To date, diagnosis and metastasis monitoring is mainly carried out through tissue biopsy and/or re-biopsy, a very invasive procedure limited only to certain locations and not always feasible in clinical practice. In order to improve disease monitoring over time and to avoid painful procedure such as tissue biopsy, liquid biopsy may represent a new precious tool. Indeed, it represents a basin of "new generation" biomarkers that are spread into the bloodstream from both primary and metastatic sites. Moreover, elevated concentrations of circulating tumor DNA (ctDNA) as well as circulating tumor cells (CTCs) have been found in blood plasma of patients with various tumor types. Nowadays, several new approaches have been introduced for the detection and characterization of CTCs and ctDNA, allowing a real-time monitoring of tumor evolution. This review is focused on the clinical relevance of liquid biopsy in breast cancer and will pr...Continue Reading

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Citations

Jul 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zibo LiJun Wang
Jul 10, 2019·Journal of Breath Research·Annalisa CampanellaStefania Tommasi
Jul 31, 2016·Oncotarget·Daniela MassihniaAntonio Russo
Oct 25, 2016·Breast Cancer Research and Treatment·Chun WangHushan Yang
Nov 29, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giovanna RossiMassimo Cristofanilli

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