A health policy model of CKD: 1. Model construction, assumptions, and validation of health consequences

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Thomas J HoergerCenters for Disease Control and Prevention CKD Initiative

Abstract

A cost-effectiveness model that accurately represents disease progression, outcomes, and associated costs is necessary to evaluate the cost-effectiveness of interventions for chronic kidney disease (CKD). We developed a microsimulation model of the incidence, progression, and treatment of CKD. The model was validated by comparing its predictions with survey and epidemiologic data sources. US patients. The model follows up disease progression in a cohort of simulated patients aged 30 until age 90 years or death. The model consists of 7 mutually exclusive states representing no CKD, 5 stages of CKD, and death. Progression through the stages is governed by a person's glomerular filtration rate and albuminuria status. Diabetes, hypertension, and other risk factors influence CKD and the development of CKD complications in the model. Costs are evaluated from the health care system perspective. Usual care, including incidental screening for persons with diabetes or hypertension. Progression to CKD stages, complications, and mortality. The model provides reasonably accurate estimates of CKD prevalence by stage. The model predicts that 47.1% of 30-year-olds will develop CKD during their lifetime, with 1.7%, 6.9%, 27.3%, 6.9%, and 4.4% e...Continue Reading

References

Feb 19, 1997·JAMA : the Journal of the American Medical Association·M G HuninkM C Weinstein
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jan 22, 2003·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Milton C WeinsteinUNKNOWN ISPOR Task Force on Good Research Practices--Modeling Studies
Dec 18, 2003·JAMA : the Journal of the American Medical Association·L Ebony BoulwareNeil R Powe
Apr 22, 2004·Journal of the American Society of Nephrology : JASN·Daniel E WeinerMark J Sarnak
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ernesto PaolettiGiuseppe Cannella
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Aug 26, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Daniel E WeinerMark J Sarnak
May 25, 2007·Nephron. Clinical Practice·Sankar D NavaneethanWajid Choudhry
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Oct 28, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jon J SnyderAllan J Collins
Apr 7, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Steven G CocaChirag R Parikh

❮ Previous
Next ❯

Citations

Dec 4, 2012·Journal of the American Society of Nephrology : JASN·Thomas J HoergerDesmond E Williams
Nov 20, 2012·Journal of the American Society of Nephrology : JASN·Roberto B Vargas, Keith C Norris
Nov 7, 2015·The New England Journal of Medicine·Robert W Steiner
Feb 18, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Paul KomendaNavdeep Tangri
Jul 31, 2012·Urology·Nicholas G CostVitaly Margulis
Jun 23, 2012·The Veterinary Clinics of North America. Small Animal Practice·Joseph W Bartges
Jul 26, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joseph A Vassalotti, Beth Piraino
Jul 26, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bryce A Kiberd
Apr 10, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Morgan E GramsJosef Coresh
Jan 11, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R W Steiner
Jun 9, 2012·The Mount Sinai Journal of Medicine, New York·Juan P RoccaMichael Edye
Dec 4, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Thomas J HoergerXiaohui Zhuo
Apr 22, 2015·Current Medical Research and Opinion·Tessa Kennedy-MartinSharon Rayner
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Aminu K BelloUNKNOWN Kidney Health for Life Initiative
Oct 10, 2015·Journal of the American Society of Nephrology : JASN·Florin L CraciunVishal S Vaidya
Feb 2, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Thomas J HoergerUNKNOWN Centers for Disease Control and Prevention CKD Initiative
Oct 16, 2015·PloS One·Andrew J SuttonUNKNOWN eGFR-C study group
Feb 1, 2017·Journal of Veterinary Internal Medicine·R JavardM Dunn
Mar 13, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R W SteinerB Gert
Aug 7, 2017·Heart·Iryna SchlackowUNKNOWN SHARP Collaborative Group
Aug 24, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert W Steiner
Feb 8, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Cheryl NeslusanLien Vo
Dec 12, 2012·Journal of the American Society of Nephrology : JASN·Eric G Neilson
Mar 16, 2017·BMC Nephrology·Benjamin O YarnoffUNKNOWN Centers for Disease Control and Prevention CKD Initiative
Dec 12, 2019·Journal of General Internal Medicine·Cara B LitvinSteven M Ornstein
Nov 14, 2016·PharmacoEconomics·Michael WillisChristian Asseburg
Dec 23, 2015·Clinical Transplantation·Robert W Steiner
Oct 27, 2017·Annual Review of Physiology·Benjamin D Humphreys
Nov 17, 2020·Hypertension·Chi D ChuUNKNOWN Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team
Apr 24, 2017·Kidney International·Thomas W FergusonPaul V J Komenda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
Thomas J HoergerDesmond E Williams
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Andrew J PalmerRoger A Rodby
Clinical Journal of the American Society of Nephrology : CJASN
Keith Norris, Allen R Nissenson
© 2021 Meta ULC. All rights reserved