PMID: 11332541May 3, 2001Paper

A health risk benchmark for the neurologic effects of styrene: comparison with NOAEL/LOAEL approach

Risk Analysis : an Official Publication of the Society for Risk Analysis
J RabovskyD C Lewis

Abstract

Benchmark dose (BMD) analysis was used to estimate an inhalation benchmark concentration for styrene neurotoxicity. Quantal data on neuropsychologic test results from styrene-exposed workers [Mutti et al. (1984). American Journal of Industrial Medicine, 5, 275-286] were used to quantify neurotoxicity, defined as the percent of tested workers who responded abnormally to > or = 1, > or = 2, or > or = 3 out of a battery of eight tests. Exposure was based on previously published results on mean urinary mandelic- and phenylglyoxylic acid levels in the workers, converted to air styrene levels (15, 44, 74, or 115 ppm). Nonstyrene-exposed workers from the same region served as a control group. Maximum-likelihood estimates (MLEs) and BMDs at 5 and 10% response levels of the exposed population were obtained from log-normal analysis of the quantal data. The highest MLE was 9 ppm (BMD = 4 ppm) styrene and represents abnormal responses to > or = 3 tests by 10% of the exposed population. The most health-protective MLE was 2 ppm styrene (BMD = 0.3 ppm) and represents abnormal responses to > or = 1 test by 5% of the exposed population. A no observed adverse effect level/lowest observed adverse effect level (NOAEL/LOAEL) analysis of the same qu...Continue Reading

Citations

Jan 1, 2008·Toxicology Mechanisms and Methods·Tian LinJin Tai-Yi
Nov 5, 2003·Critical Reviews in Toxicology·Agneta Falk FilipssonKatarina Victorin
Feb 10, 2016·Risk Analysis : an Official Publication of the Society for Risk Analysis·Håkan VigreTine Hald
Jul 3, 2003·Risk Analysis : an Official Publication of the Society for Risk Analysis·Matteo GoldoniAntonio Mutti
Feb 27, 2015·Risk Analysis : an Official Publication of the Society for Risk Analysis·Andrew A HillEmma L Snary
Nov 2, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Qin-Bao LinZhi-Wei Wang
May 15, 2007·Environmental Toxicology·Tian Lin, Jin Tai-Yi
Oct 12, 2018·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Xue-Chao SongZhi-Feng Chen
Jun 5, 2003·Environmental Health : a Global Access Science Source·Alberto Arnedo-PenaManolis Kogevinas

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