A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Danuta SosnowskaIain Ridgway

Abstract

Study of negligibly senescent animals may provide clues that lead to better understanding of the cardiac aging process. To elucidate mechanisms of successful cardiac aging, we investigated age-related changes in proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in the heart of the ocean quahog Arctica islandica, the longest-lived noncolonial animal (maximum life span potential: 508 years). We found that in the heart of A. islandica the level of oxidatively damaged proteins did not change significantly up to 120 years of age. No significant aging-induced changes were observed in caspase-like and trypsin-like proteasome activity. Chymotrypsin-like proteasome activity showed a significant early-life decline, then it remained stable for up to 182 years. No significant relationship was observed between the extent of protein ubiquitination and age. In the heart of A. islandica, an early-life decline in expression of HSP90 and five mitochondrial electron transport chain complexes was observed. We found significant age-related increases in the expression of three cytokine-like mediators (interleukin-6, interleukin-1β, and tumor necrosis factor-α) in th...Continue Reading

References

Jul 1, 1992·American Journal of Epidemiology·C J NewschafferW E Hale
Apr 25, 1992·Annals of the New York Academy of Sciences·T K HughesG B Stefano
Jan 1, 1991·Developmental and Comparative Immunology·T K HughesG B Stefano
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T K HughesG B Stefano
Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Feb 15, 1994·Archives of Biochemistry and Biophysics·S Agarwal, R S Sohal
Jan 6, 2000·Archives of Biochemistry and Biophysics·L K Kwong, R S Sohal
May 12, 2000·The Journal of Biological Chemistry·A M Cuervo, J F Dice
May 20, 2000·Annals of the New York Academy of Sciences·I AlafuzoffH Soininen
May 24, 2000·Cellular and Molecular Life Sciences : CMLS·E OttavianiS Genedani
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Nov 15, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M J ForsterR S Sohal
Mar 13, 2001·Blood Purification·C A Dinarello, B J Pomerantz
Feb 14, 2002·Archives of Biochemistry and Biophysics·Anne-Laure BulteauBertrand Friguet
May 15, 2002·Current Biology : CB·Scott D PletcherLinda Partridge
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna CsiszarGabor Kaley
Feb 26, 2004·Progress in Molecular and Subcellular Biology·E OttavianiA Franchini
Mar 17, 2004·Physiological Genomics·Anna CsiszarGabor Kaley
Apr 7, 2005·Mechanisms of Ageing and Development·Eva PhilippDoris Abele
Aug 22, 2006·Current Pharmaceutical Design·A FranchiniE Ottaviani
Sep 28, 2006·Mechanisms of Ageing and Development·Asish R ChaudhuriArlan Richardson
Mar 9, 2007·American Journal of Physiology. Cell Physiology·Sharon Judge, Christiaan Leeuwenburgh
Apr 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariAnna Csiszar
Apr 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sándor BátkaiPál Pacher
Apr 25, 2007·Hypertension·Mingyi WangEdward G Lakatta
May 1, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Anna CsiszarZoltan Ungvari
Jan 23, 2008·Biological Chemistry·Nicolle Breusing, Tilman Grune
May 20, 2008·Free Radical Research·Doris AbeleEva E R Philipp
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Zoltan UngvariAnna Csiszar
Jun 6, 2008·Mechanisms of Ageing and Development·Feng LiJeffrey N Keller
Jul 5, 2008·Journal of Applied Physiology·Anna CsiszarZoltan Ungvari
Feb 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Viviana I PérezAsish Chaudhuri
Feb 27, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Adam B SalmonAsish R Chaudhuri
Mar 10, 2009·Experimental Gerontology·Doris AbeleEva Philipp
May 27, 2009·Gerontology·Eva E R Philipp, Doris Abele
Dec 31, 2009·Current Opinion in Nephrology and Hypertension·Mingyi WangEdward G Lakatta
Feb 18, 2010·Circulation·Jaime M PredmoreSharlene M Day

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Citations

Mar 20, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Agnes CsiszárZoltan Ungvari
Jan 16, 2018·Nature Reviews. Nephrology·Peter StenvinkelRichard J Johnson
Oct 8, 2014·Nature Reviews. Nephrology·Jeroen P KoomanPeter Stenvinkel
Aug 20, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eszter BankiZoltan Ungvari
Oct 30, 2015·PloS One·Giulio ValentiKlaas R Westerterp
Oct 23, 2019·Journal of Internal Medicine·P StenvinkelB Natterson-Horowitz
Jul 16, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter StenvinkelPaul G Shiels
Aug 2, 2019·Biochemical Society Transactions·Peter Stenvinkel, Paul G Shiels
Aug 14, 2020·Cells·Emanuel BarthStefan Schuster
Oct 10, 2020·Cellular and Molecular Life Sciences : CMLS·Justyna Mikuła-PietrasikKrzysztof Książek

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