PMID: 7545209Apr 1, 1995Paper

A helper T-cell antigen enhances generation of hepatitis C virus-specific cytotoxic T lymphocytes in vitro

Journal of Medical Virology
H KitaS Ohnishi

Abstract

A T-cell helper for generation of hepatitis C virus-specific cytotoxic T lymphocytes was studied in three patients with chronic hepatitis C. In all three, human leukocyte antigen B44-restricted cytotoxic T lymphocytes recognizing an epitope in hepatitis C virus nucleocapsid protein residues 81-100 were generated from the peripheral blood lymphocytes by repeated stimulation with a synthetic hepatitis C virus nucleocapsid peptide. The proliferative response of peripheral blood lymphocytes to hepatitis C virus nucleocapsid protein residues 1-120 was observed in one patient, and was ascribed to CD4+ T cells. The helper T cells recognized a major epitope in residues 21-40 and a minor epitope(s) in residues 81-110. They produced interferon gamma, but interleukin 4 was not detectable in the T-helper cell culture supernatants. The hepatitis C virus nucleocapsid protein residues 1-120 and the major helper T-cell epitope enhanced generation of hepatitis C virus-specific cytotoxic T lymphocytes in vitro, although the protein alone did not generate them. In the other two patients, the protein did not enhance generation of hepatitis C virus-specific cytotoxic T lymphocytes in vitro. The results suggest that a hepatitis C virus-specific help...Continue Reading

References

Jan 1, 1992·International Archives of Allergy and Immunology·S Romagnani
Sep 1, 1988·The Journal of Experimental Medicine·M J CannonB A Askonas
Sep 1, 1993·European Journal of Immunology·G Stuhler, P Walden
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Citations

Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D R NelsonJ Y Lau
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G W McCaughan, A Zekry
Nov 1, 2001·Clinics in Liver Disease·D R Nelson
Nov 25, 2004·Clinics in Liver Disease·D R Nelson, J Y Lau
Dec 19, 1998·Journal of Viral Hepatitis·J A Waters
Aug 9, 2011·International Journal of Evolutionary Biology·Kristina M Sefc
Aug 1, 1995·Immunology and Cell Biology·I HaraseM Imawari
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·J L DzurisA Sette

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