A heme oxygenase-1 transducer model of degenerative and developmental brain disorders

International Journal of Molecular Sciences
H M Schipper, Wei Song

Abstract

Heme oxygenase-1 (HO-1) is a 32 kDa protein which catalyzes the breakdown of heme to free iron, carbon monoxide and biliverdin. The Hmox1 promoter contains numerous consensus sequences that render the gene exquisitely sensitive to induction by diverse pro-oxidant and inflammatory stimuli. In "stressed" astroglia, HO-1 hyperactivity promotes mitochondrial iron sequestration and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure documented in Alzheimer disease, Parkinson disease and certain neurodevelopmental conditions. Glial HO-1 expression may also impact neuroplasticity and cell survival by modulating brain sterol metabolism and the proteasomal degradation of neurotoxic proteins. The glial HO-1 response may represent a pivotal transducer of noxious environmental and endogenous stressors into patterns of neural damage and repair characteristic of many human degenerative and developmental CNS disorders.

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Citations

Sep 22, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carmela ParentiGiovanna M Scoto
Mar 1, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Wei SongHyman M Schipper
Dec 13, 2017·Medicine and Science in Sports and Exercise·Chongyun WuQuanguang Zhang
Feb 28, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Govindhasamy Pushpavathi SelvakumarAsgar Zaheer
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Dec 15, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jiayin GaoLinxi Chen
Nov 20, 2020·Redox Biology·Cristina Fernández-MendívilManuela G López
Mar 24, 2021·Psychiatry Research·Thomas BertrandHyman M Schipper
Nov 11, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Emrin HorgusluogluUNKNOWN Alzheimer Disease Metabolomics Consortium

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Methods Mentioned

BETA
X-ray
transfection
electron spin resonance
Transgenic
pharmacotherapy

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