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A Hidden Markov Model for Investigating Recent Positive Selection through Haplotype Structure

bioRxiv

Nov 8, 2014

Hua ChenMontgomery Slatkin

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Abstract

Recent positive selection can increase the frequency of an advantageous mutant rapidly enough that a relatively long ancestral haplotype will be remained intact around it. We present a hidden Markov model (HMM) to identify such haplotype structures. With HMM identified haplotype structu...read more

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Alleles
Genes
Genome
Spectrum Analysis
Asians
Stem Cell Factor
OCA2 protein, human
Oculocutaneous Albinism Type 2
Scanning
Mutant
10
2
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  • A Hidden Markov Model for Investigating Recent Positive Selection through Haplotype Structure

    bioRxiv

    Nov 8, 2014

    Hua ChenMontgomery Slatkin

    PMID: 990011247

    DOI: 10.1101/011247

    Abstract

    Recent positive selection can increase the frequency of an advantageous mutant rapidly enough that a relatively long ancestral haplotype will be remained intact around it. We present a hidden Markov model (HMM) to identify such haplotype structures. With HMM identified haplotype structu...read more

    Mentioned in this Paper

    Alleles
    Genes
    Genome
    Spectrum Analysis
    Asians
    10
    2

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