A hierarchical modelling approach to assess multi pollutant effects in time-series studies

PloS One
Marta BlangiardoGary W Fuller

Abstract

When assessing the short-term effect of air pollution on health outcomes, it is common practice to consider one pollutant at a time, due to their high correlation. Multi pollutant methods have been recently proposed, mainly consisting of collapsing the different pollutants into air quality indexes or clustering the pollutants and then evaluating the effect of each cluster on the health outcome. A major drawback of such approaches is that it is not possible to evaluate the health impact of each pollutant. In this paper we propose the use of the Bayesian hierarchical framework to deal with multi pollutant concentrations in a two-component model: a pollutant model is specified to estimate the 'true' concentration values for each pollutant and then such concentration is linked to the health outcomes in a time-series perspective. Through a simulation study we evaluate the model performance and we apply the modelling framework to investigate the effect of six pollutants on cardiovascular mortality in Greater London in 2011-2012.

References

Jan 1, 1995·Toxicology and Industrial Health·D M Drechsler-Parks
Feb 3, 2007·Epidemiology·Richard F MacLehoseJane A Hoppin
Jan 24, 2009·Environmental Health Perspectives·Joe L Mauderly, Jonathan M Samet
May 27, 2010·Epidemiology·Richard W AtkinsonBen G Armstrong
Jun 24, 2011·Environmental Health : a Global Access Science Source·Gretchen T GoldmanPaige E Tolbert
Mar 23, 2013·Journal of the Royal Statistical Society. Series C, Applied Statistics·Francesco FinazziAlessandro Fassò
May 15, 2013·Environmental Research·Anobha Gurung, Michelle L Bell
Sep 11, 2014·Organic & Biomolecular Chemistry·L F GamonU Wille
Nov 29, 2014·Air Quality, Atmosphere, & Health·M L WilliamsFrank J Kelly
Oct 16, 2015·Journal of Exposure Science & Environmental Epidemiology·Richard W AtkinsonFrank J Kelly
Jul 28, 2016·Environmental Pollution·Anna Font, Gary W Fuller
May 21, 2017·Regulatory Toxicology and Pharmacology : RTP·Elizabeth Oesterling OwensSteven J Dutton
Oct 3, 2018·International Journal of Environmental Research and Public Health·Lisha LuoMao You

Citations

Sep 29, 2020·Heliyon·Joseph Sánchez-Balseca, Agustí Pérez-Foguet

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.