A high body mass index is associated with reduced risk of rheumatoid arthritis in men, but not in women

Rheumatology
Carl TuressonLennart T H Jacobsson

Abstract

To investigate the impact of overweight and obesity on the risk of RA. From two large population-based health surveys (30 447 and 33 346 participants), individuals who developed RA after inclusion were identified by linkage to four different registers and a structured review of the medical records. Matched controls were selected from the corresponding health survey database. The impact of overweight or obesity (BMI > 25 kg/m(2)) compared with normal BMI (18.5-25 kg/m(2)) on the risk of RA was examined in conditional logistic regression models, stratified by sex. A total of 172 (36 men/136 women) and 290 (151 men/139 women) individuals were diagnosed with RA after inclusion in the two health surveys. The median time from inclusion to RA diagnosis was 5 years and 12 years, respectively. In men, being overweight or obese at inclusion in the health survey was associated with a reduced risk of subsequent development of RA in both cohorts [odds ratio (OR) = 0.33; 95% CI: 0.14, 0.76, and 0.60; 95% CI: 0.39, 0.91]. There was no such association in women (OR = 1.01; 95% CI: 0.65, 1.54, and 1.37; 95% CI: 0.86, 2.18). Estimates were similar in analyses adjusted for potential confounders, including smoking. A high BMI was associated with a...Continue Reading

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Citations

Jan 8, 2016·Current Rheumatology Reports·Michael D George, Joshua F Baker
Mar 8, 2016·Expert Review of Clinical Immunology·Barbara TolussoElisa Gremese
Dec 29, 2016·Rheumatology·Jacob M van Laar
Mar 9, 2017·Arthritis Research & Therapy·Peter OlssonElke Theander
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Feb 1, 2019·Journal of Cachexia, Sarcopenia and Muscle·Jian-Zi LinLie Dai
Jun 7, 2019·RMD Open·Anna Karin HedströmLars Alfredsson
Oct 16, 2015·Arthritis Research & Therapy·Carl TuressonLennart Th Jacobsson
Nov 30, 2016·Arthritis Research & Therapy·Lotta Ljung, Solbritt Rantapää-Dahlqvist
Apr 30, 2017·Seminars in Immunopathology·Deshiré Alpízar-Rodríguez, Axel Finckh
Jan 6, 2021·Nutrients·Deshiré Alpízar-RodríguezBenoît Gilbert
Dec 10, 2017·Best Practice & Research. Clinical Rheumatology·Kevin D DeaneV Michael Holers

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