A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population

Clinical & Translational Immunology
Silvia LeePatricia Price

Abstract

Meta-analyses have now confirmed that persistent infections with cytomegalovirus (CMV) can accelerate the onset of diseases of ageing, notably cardiovascular pathologies. We address the circumstances in which the association may be strong enough to warrant intervention to reduce the viral burden. We compare markers of the burden of CMV with established indices of vascular pathology in healthy adults (n = 82) and in renal transplant recipients (RTR; n = 81). Levels of all inflammatory and vascular biomarkers and CMV antibodies were higher in RTR, and flow-mediated dilation (FMD) values were lower indicating inferior endothelial function. In multivariable regression models without adjustment for estimated glomerular filtration rate (eGFR), CMV antibody levels, age and gender were independently associated with FMD in RTR, whilst only CRP associated with FMD in healthy adults. After adjustment for eGFR, associations between CMV antibody and FMD in RTR were reduced. Carotid intima-media thickness, FMD, eGFR and plasma levels of CMV antibodies (reactive with a lysate, CMV IE-1 or CMV gB), ICAM-1, VCAM-1, P-selectin, sIFNαR2, sTNFR1, sCD14 and CRP were determined. Levels of CMV antibody predict declining endothelial health in RTR and ...Continue Reading

References

Feb 1, 1994·Journal of Medical Virology·J L MelnickM E DeBakey
May 3, 2000·Clinical and Experimental Immunology·I NordøyS S Frøland
Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
Feb 19, 2002·Neurobiology of Disease·Woan-Ru LinRuth F Itzhaki
Jan 23, 2003·Circulation·Marek SmiejaUNKNOWN Heart Outcomes Prevention Evaluation (HOPE) Study Investigators
Apr 2, 2003·Journal of Virological Methods·Barbara ReinhardtThomas Mertens
Mar 6, 2007·Experimental Gerontology·Raymond P StoweRonald Glaser
Dec 17, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sara Gredmark-RussCecilia Söderberg-Nauclér
Dec 26, 2008·International Journal of Epidemiology·Amanda M SimanekAllison E Aiello
Jun 22, 2010·Reviews in Medical Virology·Michael J CannonTerri B Hyde
Jul 17, 2010·The Journal of Infectious Diseases·Pablo J van de BergIneke J ten Berge
Sep 15, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Shamila Karuthu, Emily A Blumberg
Feb 19, 2013·The Journal of Infectious Diseases·Cécile CourivaudDidier Ducloux
Jul 15, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Ruben PoesenDominic S Raj
Jan 14, 2016·Journal of Clinical Immunology·Fathiah S AmranPatricia Price
Nov 2, 2016·Journal of Medical Virology·Patricia PriceAshley Irish
Jan 1, 2017·Mechanisms of Ageing and Development·Daniela MontiClaudio Franceschi
Nov 8, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shelley WatersPatricia Price

❮ Previous
Next ❯

Citations

Jun 17, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Endah A T WulandariPatricia Price
Oct 28, 2019·International Journal of Molecular Sciences·Shelley WatersPatricia Price
Aug 1, 2020·Frontiers in Cellular and Infection Microbiology·Jennifer N StylesAndrey I Egorov
Dec 20, 2019·Expert Review of Anti-infective Therapy·Isabel Rodríguez-GoncerJosé María Aguado
Jun 3, 2021·Pathogens·Cassandra M Bonavita, Rhonda D Cardin

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad Prism
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.