PMID: 15366638Sep 16, 2004Paper

A high carbohydrate diet induces insulin resistance through decreased glucose utilization in ovariectomized rats

The Korean Journal of Internal Medicine
Sun Min ParkSoo Bong Choi

Abstract

Recent research has reported that high sugar diets increase insulin resistance, without abdominal obesity, in male, but not female Wistar rats. Whether a high sucrose (SU) diet increased insulin resistance in ovariectomized (OVX) rats was determined. Female Sprague Dawley rats, weighing 273 +/- 20 g, had either an ovariectomy or a sham operation (sham). OVX and sham rats were divided into two groups: one group had a 68 En% SU diet and the other a 68 En% starch (ST) diet for 8 weeks. The body weight was higher in the OVX than the sham rats, regardless of dietary carbohydrate subtype. The fasting serum glucose levels did not differ according to diet and ovariectomy. However, the fasting serum insulin levels were higher in the OVX than the sham rats, and in the OVX rats, a high SU diet increased the serum insulin levels more than a high ST diet. The whole body glucose disposal rates, which referred to the state of insulin sensitivity, were lower in the OVX rats fed both the high SU and ST diets, compared to sham rats. Glycogen deposits in the soleus and quadriceps muscles were lower in the OVX rats fed high SU and ST diets than in sham rats. The glucose transporter 4 content and fraction velocity of glycogen synthase in muscles sh...Continue Reading

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Citations

Dec 22, 2011·Climacteric : the Journal of the International Menopause Society·D BaxiA V Ramachandran
Feb 7, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M L Medina-ContrerasG Bravo
Feb 28, 2020·Journal of the Science of Food and Agriculture·Juana Maria de Lourdes Medina-ContrerasGuadalupe Bravo
Apr 4, 2013·American Journal of Physiology. Endocrinology and Metabolism·Lindsay M WohlersEspen E Spangenburg

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