PMID: 3762319Aug 1, 1986Paper

A high cholesterol/cholate diet induced fatty liver in spontaneously hypertensive rats

Lipids
K Ueno, H Okuyama

Abstract

A high cholesterol diet was found to induce fatty liver in spontaneously hypertensive rats. Although cholesterol ester and triacylglycerol accumulated in large amounts in liver, the increases of these lipids in plasma were relatively small and no increase in cholesterol and cholesterol ester was observed in aorta. In rats fed normal diet, plasma cholesterol ester mainly consisted of arachidonate species; however, oleate and linoleate esters became the most prominent species in rats fed a high-cholesterol diet. The amounts of oleate and linoleate at the 2-position of phosphatidylcholine in both plasma and liver were increased slightly, but the fatty acids of aorta lipids changed little by feeding a high cholesterol diet. These results indicate that the livers of rats fed the high cholesterol diet do not secrete cholesterol ester and triacylglycerol with altered fatty acids as rapidly as they are synthesized and that the increased levels of cholesterol oleate in liver and plasma are not directly correlated with atherogenic lesions under these conditions.

References

Nov 1, 1977·Atherosclerosis·N IritaniY Yamori
Jan 1, 1978·Lipids·K UchidaN Takeuchi
Oct 1, 1978·European Journal of Biochemistry·S BalasubramaniamS Venkatesan
Jan 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·G AssmannD Lekim
Mar 1, 1973·Japanese Circulation Journal·Y Hata, W Insull
Sep 25, 1973·Biochimica Et Biophysica Acta·P BrecherA V Chobanian
Aug 1, 1974·The Journal of Clinical Investigation·S N JagannathanA K Bhattacharyya
Jul 1, 1974·Postgraduate Medical Journal·K J KingsburyD M Morgan
Feb 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·K T Stokke, K R Norum
Aug 1, 1970·The Journal of Clinical Investigation·P D Lang, W Insull
Mar 1, 1967·Journal of Atherosclerosis Research·E B SmithM D Downham
Apr 15, 1981·Biochemical Pharmacology·G KiselevP Oehme
Sep 1, 1982·Archives of Gerontology and Geriatrics·K UchidaY Ishikawa
Apr 15, 1981·Archives of Biochemistry and Biophysics·D A WhiteG D Bell
Sep 1, 1981·Japanese Circulation Journal·Y YamoriN Iritani
Apr 1, 1995·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Y KamiyaT Fujinami
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
Jan 1, 1964·Archives of Biochemistry and Biophysics·L SWELLC R TREADWELL

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.