Apr 17, 2004

A high-density admixture map for disease gene discovery in african americans

American Journal of Human Genetics
Michael W SmithDavid E Reich

Abstract

Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with approximately 100 times fewer markers than are required for whole-genome haplotype scans. However, it has not been possible to perform powerful scans with admixture mapping because the method requires a dense map of validated markers known to have large frequency differences between Europeans and Africans. To create such a map, we screened through databases containing approximately 450000 single-nucleotide polymorphisms (SNPs) for which frequencies had been estimated in African and European population samples. We experimentally confirmed the frequencies of the most promising SNPs in a multiethnic panel of unrelated samples and identified 3011 as a MALD map (1.2 cM average spacing). We estimate that this map is approximately 70% informative in differentiating African versus European origins of chromosomal segments. This map provides a practical and powerful tool, which is freely available without restriction, for screening for disease genes in African American patient cohorts. The map is especially appropriate for those diseases th...Continue Reading

  • References32
  • Citations304

References

  • References32
  • Citations304

Citations

Mentioned in this Paper

Genome
Chromosome Map
Dysequilibrium Syndrome
Genetics, Population
Recombination, Genetic
Spastic Syndrome
Candidate Gene Identification
Genetic Markers
Prostate Carcinoma
Genome Mapping

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