A high-fat diet can affect bone healing in growing rats

Journal of Bone and Mineral Metabolism
Jéssica Suzuki YamanakaA C Shimano

Abstract

A high-fat diet (HFD) can have a negative effect on bone quality in young and old people. Although bone healing in children is normally efficient, there is no evidence that children who have a diet rich in fat have compromised bone fracture regeneration compared with children with recommended dietary fat levels. The purpose of the present study was to evaluate the effects of an HFD on bone healing in growing female rats. Twenty-six postweaning female Wistar rats were divided into two groups (13 animals per group): a standard diet (SD) group and an HFD (with 60% of energy from fat) group. The rats received the assigned diets for 5 weeks, and in the third week they were submitted to an osteotomy procedure of the left tibia. Body mass and feed intake were recorded during the experiment. One day before euthanasia, an insulin tolerance test was performed. After euthanasia, the tibiae were removed and analyzed by densitometry, mechanical testing, histomorphometry, stereology and immunohistochemistry. An HFD caused an adaptive response to maintain energetic balance by decreasing feed intake and causing insulin insensitivity. There was no change in bone mineral density, collagen amount and immunostaining for bone formation, but maximal...Continue Reading

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Citations

Jan 19, 2018·Scandinavian Journal of Medicine & Science in Sports·R C ShimanoJ P M Issa
Jun 11, 2019·Journal of Biomaterials Science. Polymer Edition·Bruna Leonel CarlosAntônio Carlos Shimano
Feb 13, 2020·Brazilian Oral Research·Serkan DundarMerve Yilmaz Bozoglan

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