A high-fat diet impacts memory and gene expression of the head in mated female Drosophila melanogaster

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Osvaldo RiveraMatthew Talbert

Abstract

Obesity predisposes humans to a range of life-threatening comorbidities, including type 2 diabetes and cardiovascular disease. Obesity also aggravates neural pathologies, such as Alzheimer's disease, but this class of comorbidity is less understood. When Drosophila melanogaster (flies) are exposed to high-fat diet (HFD) by supplementing a standard medium with coconut oil, they adopt an obese phenotype of decreased lifespan, increased triglyceride storage, and hindered climbing ability. The latter development has been previously regarded as a potential indicator of neurological decline in fly models of neurodegenerative disease. Our objective was to establish the obesity phenotype in Drosophila and identify a potential correlation, if any, between obesity and neurological decline through behavioral assays and gene expression microarray. We found that mated female w1118 flies exposed to HFD maintained an obese phenotype throughout adult life starting at 7 days, evidenced by increased triglyceride stores, diminished life span, and impeded climbing ability. While climbing ability worsened cumulatively between 7 and 14 days of exposure to HFD, there was no corresponding alteration in triglyceride content. Microarray analysis of the ...Continue Reading

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Citations

Oct 3, 2020·International Journal of Molecular Sciences·Joo Young LeeChong Kun Cheon
May 14, 2019·Genes & Nutrition·Nieves Baenas, Anika E Wagner
Nov 10, 2020·Science China. Life Sciences·Xiaohong ZhengGuangcun He
Nov 11, 2020·Insect Biochemistry and Molecular Biology·Sifang LiaoDick R Nässel
Apr 30, 2021·Insect Biochemistry and Molecular Biology·Umut Toprak, Laura Palanker Musselman
Jul 30, 2021·Development·Scott A KeithBrooke M McCartney

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Methods Mentioned

BETA
PCR
glycosylation
RNA-Seq

Software Mentioned

JMP
Database for Annotation , Visualization and Integrated Discove...
DAVID

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