A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat

Autonomic & Autacoid Pharmacology
H A PeredoA M Puyó

Abstract

In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2 , PGF2 alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the oth...Continue Reading

References

Jul 1, 1995·The American Journal of Physiology·L J AroneJ Hirsch
Oct 2, 2004·Autonomic & Autacoid Pharmacology·A M PuyóH A Peredo
Nov 23, 2005·Journal of Human Hypertension·P Valensi
Jun 20, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Anita D Smith, Anne M Dorrance
Sep 14, 2006·Autonomic & Autacoid Pharmacology·H A PeredoE Filinger
Jan 15, 2008·Journal of the American College of Cardiology·Ronald M Witteles, Michael B Fowler
May 14, 2008·Current Hypertension Reports·Marion R WoffordDeborah S Minor
Sep 30, 2008·Experimental Physiology·Francesco Di NardoPiero Ruggeri
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Michael D Jensen
Dec 8, 2009·Nature Medicine·Mitchell A Olman
Oct 23, 2010·Journal of Cardiovascular Pharmacology·Sunil K PanchalLindsay Brown
Oct 28, 2010·Nutrition Research Reviews·Niloofar Hariri, Louise Thibault
May 17, 2011·Journal of Cardiovascular Pharmacology·Sunil K PanchalLindsay Brown
May 21, 2011·Lipids in Health and Disease·Tatyana P NovgorodtsevaTatyana A Kantur
Apr 5, 2013·Journal of Biomedical Research·Yaping WangGang Tian
Feb 7, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wen-yuan DingWei Zhang

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Citations

Jun 18, 2017·Autonomic & Autacoid Pharmacology·H J LeeA M Puyó
Oct 22, 2020·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Hyun J LeeMarcelo R Choi

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