A high frequency of macrolide-lincosamide-streptogramin resistance determinants in Staphylococcus aureus isolated in South Korea

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Hong Bin KimKang Won Choe

Abstract

Genes conferring resistance to one of the macrolide-lincosamide-streptogramin (MLS) antibiotics may confer cross-resistance to others, because they have similar effects on bacterial protein synthesis. In Korea, over 70% of Staphylococcus aureus isolates are methicillin-resistant and erythromycin-resistant methicillin-resistant S. aureus (MRSA) is also prevalent. We investigated the frequency of MLS resistance in erythromycin-resistant S. aureus isolates. A total of 682 isolates of S. aureus were collected in a nationwide antibiotic resistance survey. Susceptibility to erythromycin, clindamycin, and quinupristin/dalfopristin was tested by disk diffusion. In all, 37% of the methicillin-susceptible S. aureus (MSSA) and 97% of the MRSA isolates were resistant to at least one of the MLS antibiotics, whereas all were susceptible to quinupristin/dalfopristin. Out of 518 strains that were resistant to erythromycin, 60 clindamycin-susceptible (30 MSSA, 30 MRSA) and 44 clindamycin-resistant isolates (14 MSSA, 30 MRSA) were selected at random from these strains. Thirteen genes related to MLS resistance were detected in these isolates by PCR. Of the 104 MSSA and MRSA strains tested, 98 harbored one or more erm gene. The most common was erm...Continue Reading

References

May 1, 1991·Antimicrobial Agents and Chemotherapy·R L DavisJ Neidhart
Sep 1, 1987·Antimicrobial Agents and Chemotherapy·C R MarchbanksR L White
Dec 1, 1987·Antimicrobial Agents and Chemotherapy·R LeclercqP Courvalin
Mar 1, 1995·Antimicrobial Agents and Chemotherapy·B Weisblum
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·D J MasonV A Gant
Jul 1, 1997·The Journal of Antimicrobial Chemotherapy·K HiramatsuF C Tenover
Aug 26, 1998·The New England Journal of Medicine·F D Lowy
Aug 25, 1999·The Journal of Antimicrobial Chemotherapy·V A LunaM C Roberts
Apr 11, 2001·Emerging Infectious Diseases·F C TenoverM V Lancaster
Aug 2, 2001·The Journal of Antimicrobial Chemotherapy·D DrinkovicR Ellis-Pegler
Jan 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roland Leclercq
Feb 2, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·G ClareboutR Leclercq
Aug 2, 2002·Molecular Cell·Jeffrey L HansenThomas A Steitz
Jun 7, 2003·Journal of Clinical Microbiology·Hong Bin KimKang Won Choe
Nov 10, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·N El Solh, J Allignet

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Citations

Jan 2, 2007·The Pediatric Infectious Disease Journal·Gerdien A Tramper-StrandersCornelis K van der Ent
Jul 1, 2014·The Orthopedic Clinics of North America·Beau S KonigsbergKevin L Garvin
Nov 2, 2011·Burns : Journal of the International Society for Burn Injuries·Shadi ShahsavanMorovat Taherikalani
Jul 18, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Z SaribasA Pinar
Aug 2, 2005·Clinical Orthopaedics and Related Research·Ivan S TarkinKevin L Garvin

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