A high level of urinary retinol-binding protein is associated with cytomegalovirus infection in kidney transplantation

Clinical Science
L R Requião-MouraA Pacheco-Silva

Abstract

The indirect effects of cytomegalovirus (CMV) viremia can be related to chronic changes in renal allograft structure, but its real impact in early and late graft function remains speculative. A total of 159 patients undergoing renal transplantation using a preemptive therapeutic strategy to prevent CMV disease were included in the present study. The patients were prospectively followed, with serial measurements of urinary retinol-binding protein (uRBP), a marker of proximal tubule injury. uRBP levels and their dynamic performance were compared according to CMV viremia and the 5-year estimated glomerular filtration rate (eGFR), as measured with the modification of diet in renal disease (MDRD) equation. CMV viremia was detected in 79.9% of the patients, with high uRBP levels being detected in 76.0% of these patients (compared with 40.7% in CMV-, P=0.005). High uRBP was associated with male recipients (P=0.02), the number of mismatches (P=0.02) and CMV infection (P=0.001). Five-year eGFR was worse in patients with high uRBP levels (50.3 ± 25.8 compared with 59.8 ± 26.4 ml/min, P=0.04). In a multivariate model, eGFR <60 ml/min was associated with donor age (P<0.001), the number of mismatches (P=0.04), thymoglobulin dose (P=0.02), t...Continue Reading

References

Nov 1, 1991·Kidney International·J A UstinovI T Lautenschlager
Jul 9, 1981·The New England Journal of Medicine·W P RichardsonR H Rubin
Apr 19, 2002·Nephron·Gianna Mastroianni KirsztajnAparecido B Pereira
May 1, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kaija InkinenIrmeli Lautenschlager
Nov 30, 2004·The Lancet Infectious Diseases·Maher K Gandhi, Rajiv Khanna
Feb 18, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ilkka HelanteräIrmeli Lautenschlager
Apr 15, 2005·Journal of the American Society of Nephrology : JASN·Camille N Kotton, Jay A Fishman
May 25, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Kaija InkinenIrmeli Lautenschlager
Mar 15, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tomás ReischigVladislav Treska
Oct 5, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Ilkka HelanteräIrmeli Lautenschlager
Jan 22, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Fausto BaldantiGiuseppe Gerna
Feb 12, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V KliemF Rohde
Jun 20, 2008·International Journal of Clinical Practice·A PrakashC H Mallinckrodt
Sep 18, 2012·Journal of Diabetes and Its Complications·S M TitanR Zatz
Jul 31, 2013·Transplantation·Camille N KottonUNKNOWN Transplantation Society International CMV Consensus Group
Feb 11, 2015·World Journal of Nephrology·Salvador Lopez-Giacoman, Magdalena Madero
Dec 19, 2015·PloS One·Tainá Veras de Sandes-FreitasJosé Osmar Medina-Pestana

❮ Previous
Next ❯

Citations

Feb 16, 2021·Journal of Medical Biochemistry·Chuang LiWeidong Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.