PMID: 15244224Jul 13, 2004Paper

A high neonatal serum eosinophil cationic protein level is a risk factor for atopic symptoms

Acta Paediatrica
G MontiC Fabris

Abstract

To show whether neonatal eosinophil counts (EC) and eosinophil cationic protein (ECP) can be used in assessing the risk of atopy, alone or in combination with family history of atopy (FHa). A group of 63 newborns was included: 38 with FHa, 25 without FHa. A blood sample was collected on the 4th day of life for EC and ECP evaluation. Clinical follow-up was conducted after 1, 3, 6, 12, 18, 24 and 36 mo. The chi2 test and the Student's t-test were used to compare dichotomic and continuous variables, respectively. Variables shown to be significant by univariate analysis were evaluated with a multivariate regression model and the relative risks (RR) were estimated. Twenty-six newborns (41%) displayed atopic manifestations during the follow-up. Twenty-one (55%) of 38 newborns with FHa displayed atopic symptoms versus 5/25 (20%) without FHa (p 0.012). Neither EC nor serum ECP levels were significantly different between newborns with FHa and newborns without. ECP levels did not differ between newborns with single heredity and newborns with dual heredity. EC did not differ significantly between newborns who developed atopy and those who did not. Instead, serum ECP levels were significantly higher in newborns who developed atopy (mean 27...Continue Reading

References

Feb 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T SugaiS Matumoto
Sep 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H KlementssonU Pipkorn
Jan 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G HattevigN I Kjellman
Jun 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M P BorresB Björkstén
Jan 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·L G Hansen
Apr 1, 1997·Clinical Otolaryngology and Allied Sciences·Y OhashiA Tanaka
Jun 1, 1997·The Journal of Allergy and Clinical Immunology·D Y KollerT Frischer
Jun 1, 1997·Pediatric Pulmonology·T M ReijonenK Remes
Jul 7, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·N I Kjellman, L Nilsson
Feb 16, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A KaanM Chan-Yeung
Dec 8, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·K OymarR Bjerknes
Jul 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V H van der VeldenH F Savelkoul

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Citations

Jan 2, 2013·Allergologia et immunopathologia·Aravind Yadav, Rakesh Naidu

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