PMID: 39990Aug 1, 1979

A high performance liquid chromatographic assay of cis- and trans- isomers of tricyclic neuroleptic drugs

The Journal of Pharmacy and Pharmacology
A Li Wan Po, W J Irwin

Abstract

Tricyclic neuroleptics based upon the thioxanthene nucleus exhibit geometrical isomerism and the major pharmacological activity resides in the Z-component. An h.p.l.c. procedure which enables the separation detection and quantification of these isomers is described. The method is applicable to the analysis of flupenthixol, clopenthixol, chlorprothixene, doxepin and dothiepin. Measurement of the isomer-ratios in various samples of flupenthixol has shown that small batch to batch variations are apparent. The determination of the isomer-ratio in formulations has been shown to rely upon the complete extraction of the medicament. This is due to the differential release of the components from the tablet matrix with the cis-isomer being favoured. There is little difference observed between the adsorption isotherms of the two components (onto charcoal) but in competition experiments differential adsorption may be demonstrated. This has clear implications for the pharmacokinetics of these drugs.

References

Feb 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·G M DuignanG G Skellern
Jan 19, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·S WalterJ Brockmöller
May 20, 1998·Journal of Pharmaceutical and Biomedical Analysis·F BelalF A Aly
Aug 27, 2009·Photochemistry and Photobiology·Luis E PiñeroMiguel A Miranda
Jan 1, 1980·The Journal of Pharmacy and Pharmacology·A Li Wan Po, W J Irwin

Citations

Jan 1, 1976·The Journal of Pharmacy and Pharmacology·O M Bakke, J Segura
Jan 31, 1977·Psychopharmacology·H Y MeltzerV S Fang
Aug 1, 1975·The Journal of Pharmacy and Pharmacology·A S HornO Kennard
Jul 1, 1976·Journal of Pharmaceutical Sciences·C K WongK P Munnelly
Mar 28, 1973·Journal of Chromatography·A de Leenheer
Jan 1, 1973·Acta Pharmacologica Et Toxicologica·I M NielsenA V Christensen
Jan 1, 1971·Acta Pharmacologica Et Toxicologica·A JorgensenV Hansen
Jan 1, 1969·Acta Pharmacologica Et Toxicologica·A JorgensenA R Khan
Aug 1, 1969·Biochemical Pharmacology·D C Hobbs
May 12, 1977·Nature·T J CrowE C Johnstone

Related Concepts

Antipsychotic Effect
Molecular Stereochemistry
Thioxanthene [EPC]
Medicament
Doxepin
Cell Nucleus
Adsorption
Charcoal
Antipsychotic Agents
Clopenthixol

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here