PMID: 16614413Apr 15, 2006Paper

A high-protein, high-fat, carbohydrate-free diet reduces energy intake, hepatic lipogenesis, and adiposity in rats

The Journal of Nutrition
Lisa PichonDaniel Tomé

Abstract

The aim of this work was to determine the effects in rats of ingesting 1 of 3 diets with normal or high protein concentrations and various carbohydrate:lipid ratios on weight gain, body composition, and the development and metabolism of white adipose tissue (WAT). For this purpose, male Wistar rats were fed for 20 or 42 d a high-carbohydrate, low-fat, normal-protein diet (76, 10, and 14% of energy as carbohydrate, lipid, and protein, respectively, carbohydrate:lipid ratio (C/L) = 7.6), a normal-carbohydrate, low-fat, high-protein diet (35, 10, and 55% of energy as carbohydrate, lipid, and protein respectively, C:L = 3.5), or a carbohydrate-free, high-fat, high-protein diet (45 and 55% of energy as fat and protein, respectively, C:L = 0). Growth, food intake, body composition, WAT cellularity, and several markers of lipogenesis including fatty acid synthase and lipoprotein lipase activities were measured in adipose tissue and liver. Lowering the C:L ratio reduced the development of WAT, weight gain, body fat mass, and adipocyte size, and in rats fed the carbohydrate-free diet (C:L = 0), the total number of adipocytes in subcutaneous WAT. These reductions in adipose tissue development with decreases in the C:L ratio of the diet s...Continue Reading

References

Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Mar 1, 1973·The Biochemical Journal·A P Halestrap, R M Denton
Apr 1, 1967·The American Journal of Physiology·R B Goldrick
Nov 1, 1983·The Journal of Nutrition·R W Swick, C L Gribskov
Mar 1, 1984·Metabolism: Clinical and Experimental·H SchmidR H Migliorini
Jan 1, 1997·Annual Review of Nutrition·H C TowleH M Shih
Feb 24, 2001·The Journal of Nutrition·C JeanD Tomé
Jun 14, 2002·Physiology & Behavior·Ahmed BensaïdGilles Fromentin
May 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Magali LacroixJean-François Huneau

❮ Previous
Next ❯

Citations

Oct 2, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Isabelle A Leclercq, Yves Horsmans
Sep 10, 2009·American Journal of Physiology. Endocrinology and Metabolism·Nattida ChotechuangDaniel Tomé
Jun 19, 2010·Experimental Biology and Medicine·Ren-Ying XuWei Cai
Apr 15, 2010·Annals of the New York Academy of Sciences·Lise Madsen, Karsten Kristiansen
Oct 28, 2010·Nutrition Research Reviews·Niloofar Hariri, Louise Thibault
Mar 28, 2017·Obesity Surgery·Joana RossellJuan Antonio Baena-Fustegueras
Nov 7, 2017·International Journal of Food Sciences and Nutrition·Gianluca GiubertiFilippo Rossi
Jan 12, 2019·Frontiers in Physiology·Lise MadsenKarsten Kristiansen
Mar 31, 2016·American Journal of Physiology. Endocrinology and Metabolism·Pia KiilerichKarsten Kristiansen
Jul 31, 2009·The American Journal of Clinical Nutrition·Daniel ToméGilles Fromentin
Nov 3, 2010·Stress : the International Journal on the Biology of Stress·A Nadal-CasellasI Llad
Dec 6, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Mylène PotierDaniel Tomé
Oct 23, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Weiwei DaiSandrine Skiba-Cassy
Aug 20, 2015·The British Journal of Nutrition·Catherine ChaumontetDaniel Tomé
Mar 31, 2016·International Journal of Molecular Sciences·David HoughtonMichael Trenell
Dec 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dalila Azzout-MarnicheDaniel Tomé
Oct 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laure ChevalierClaire Gaudichon
Apr 20, 2007·The British Journal of Nutrition·Aml ErhumaAndrew J Bennett
Apr 1, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dalila Azzout-MarnichePatrick C Even
Sep 2, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Magdalena StepienClaire Gaudichon
Jan 10, 2018·Frontiers in Physiology·Lise MadsenKarsten Kristiansen
Dec 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ousseynou SarrIsabelle Louveau
Nov 25, 2020·International Journal of Molecular Sciences·Rosa LombardiAnna Ludovica Fracanzani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.