A high protein low fat meal does not influence glucose and insulin responses in obese individuals with or without type 2 diabetes

Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association
E PapakonstantinouA Zampelas

Abstract

When substituted for carbohydrate in a meal, dietary protein enhances glycaemic control in subjects with type 2 diabetes (DM2). It is unknown whether the effect is a result of increased protein or reduced carbohydrate. The present study aimed to compare the effects of two meals differing in protein to fat ratios on post-prandial glucose and insulin responses. This was a crossover, blind study in which obese subjects with (n = 23) and without (n = 26) DM2 consumed two meals in random order with equal amounts of energy (3.1 MJ, 741 kcal), fibre and carbohydrates and a 1-week washout period. Meals were a high protein, low fat (30% protein, 51% carbohydrates, 19% fat) meal and a low protein, high fat (15% protein, 51% carbohydrates, 34% fat) meal. Subjects were matched for age and body mass index. Plasma glucose and insulin were measured at fasting, 30, 60, 90, 120 min post-prandially. Insulin resistance and insulin sensitivity were assessed. There was no significant meal effect on glucose and insulin responses within groups. Glucose response was higher in diabetic (120 min 11 +/- 0.7 mmol L(-1)) compared to nondiabetic (120 min 5 +/- 0.2; P < 0.001) subjects. Diabetic subjects had significantly higher insulin resistance (P < 0.001...Continue Reading

References

Jan 1, 1976·Annual Review of Physiology·J E GerichG M Grodsky
Dec 1, 1986·The American Journal of Clinical Nutrition·P A KrezowskiN H Bartosh
Feb 13, 2002·European Journal of Clinical Nutrition·A TrichopoulouD Trichopoulos
Dec 21, 2002·The British Journal of Nutrition·M D RobertsonK N Frayn
Oct 3, 2003·The American Journal of Clinical Nutrition·Mary C GannonHeidi Hoover
Jul 17, 2004·European Journal of Clinical Investigation·G DimitriadisS A Raptis
Oct 28, 2004·Nutrition & Metabolism·Frank Q Nuttall, Mary C Gannon
Sep 28, 2005·Diabetes Care·Emilia PapakonstantinouChristodoulos Stefanadis
Dec 25, 2007·Journal of the American Dietetic Association·Julienne K KirkKaren L Margolis
Jan 10, 2008·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

Apr 16, 2016·The American Journal of the Medical Sciences·Marion J Franz
Dec 21, 2013·Diabetes Care·Alison B EvertWilliam S Yancy
Oct 11, 2013·Diabetes Care·Alison B EvertUNKNOWN American Diabetes Association
Jan 21, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Lisa K Mathew, Cynthia Ko
Nov 1, 2017·Journal of Cheminformatics·Oya Gürsoy, Martin Smieško
Oct 17, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Monique E FrancoisJonathan P Little

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.