PMID: 2110534Apr 24, 1990Paper

A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease

FEBS Letters
R WeilerH Winkler

Abstract

Chromogranin A and synaptin/synaptophysin were characterized by immunological methods in human autopsy brain tissue from patients with Alzheimer's and Pick's disease. In immunoblots there was no qualitative difference between the antigens in control and diseased brain, but significant quantitative differences were found. In all Alzheimer cases there was a significantly lower level of synaptin/synaptophysin, whereas chromogranin A was higher in 4 out of 5 cases and in all cases relative to synaptin/synaptophysin. An analogous finding was obtained for Pick's disease. Immunohistologically a consistent staining of neuritic plaques for chromogranin A, but not for secretogranin II was found in Alzheimer cases. In Pick's disease the characteristic Pick bodies showed an analogous specific immunostaining.

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Citations

Oct 23, 2002·Journal of Neuroscience Research·Bruce Teter, J Wesson Ashford
Jan 1, 1991·Acta Neuropathologica·E MasliahR D Terry
Apr 25, 2009·Acta Neuropathologica·Thomas Arendt
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Apr 17, 2013·Journal of Neural Transmission·Michaela KaiserováPetr Kaňovský
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Jun 1, 1996·Behavioural Brain Research·H Lassmann
Apr 1, 1993·Neurochemistry International·L DillenW De Potter
May 1, 1992·Neurobiology of Aging·W G HonerP Davies
May 1, 1993·Neurobiology of Aging·D T O'ConnorL J Thal
Mar 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Hoyer
Aug 1, 1992·Neuroscience·H Winkler, R Fischer-Colbrie
May 5, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T Arendt
Sep 30, 1998·The European Journal of Neuroscience·W A KaufmannJ Marksteiner
Sep 24, 1993·Annals of the New York Academy of Sciences·H LassmannK Jellinger
Aug 25, 2011·Endocrine Reviews·Alessandro BartolomucciStephen R J Salton
Mar 4, 2005·Biological & Pharmaceutical Bulletin·Naosuke NakamuraAkira Kurosaka
Jan 19, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martijn C de WildeEliezer Masliah
May 15, 2012·Biochemical and Biophysical Research Communications·Dong-Hee ChoiJongmin Lee
Dec 8, 2015·Journal of Alzheimer's Disease : JAD·Julie VallortigaraPaul T Francis
May 1, 1991·Neuron·E MasliahT Saitoh
Nov 6, 2004·Reviews in the Neurosciences·Tara L Spires, Bradley T Hyman
Apr 1, 1992·Reviews in the Neurosciences·E MasliahT Saitoh

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