A high red blood cell distribution width predicts failure of arteriovenous fistula.

PloS One
Krzysztof BojakowskiPiotr Religa

Abstract

In hemodialysis patients, a native arteriovenous fistula (AVF) is the preferred form of permanent vascular access. Despite recent improvements, vascular access dysfunction remains an important cause of morbidity in these patients. In this prospective observational cohort study, we evaluated potential risk factors for native AVF dysfunction. We included 68 patients with chronic renal disease stage 5 eligible for AVF construction at the Department of General and Vascular Surgery, Central Clinical Hospital Ministry of Internal Affairs, Warsaw, Poland. Patient characteristics and biochemical parameters associated with increased risk for AVF failure were identified using Cox proportional hazards models. Vessel biopsies were analyzed for inflammatory cells and potential associations with biochemical parameters. In multivariable analysis, independent predictors of AVF dysfunction were the number of white blood cells (hazard ratio [HR] 1.67; 95% confidence interval [CI] 1.24 to 2.25; p<0.001), monocyte number (HR 0.02; 95% CI 0.00 to 0.21; p = 0.001), and red blood cell distribution width (RDW) (HR 1.44; 95% CI 1.17 to 1.78; p<0.001). RDW was the only significant factor in receiver operating characteristic curve analysis (area under th...Continue Reading

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Citations

Jan 2, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Richard WarwickMichael Poullis
Sep 5, 2015·Renal Failure·Maria Guedes MarquesPedro Ponce
Jan 28, 2017·The Journal of Vascular Access·Anna ValerianovaJan Malik
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May 27, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mehmet E MemetoğluMahmut M Demіrtas
Jun 20, 2018·Clinical Hemorheology and Microcirculation·Souleiman GhanemNorbert Nemeth
Mar 21, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Da Jung JungKyu-Yup Lee
Mar 6, 2021·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Iman RamzyNader Bakheet

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Methods Mentioned

BETA
biopsies

Software Mentioned

GraphPad Prism
MedCalc

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