A high-resolution genetic map of the nervous locus on mouse chromosome 8

Genomics
P L De JagerN Heintz

Abstract

The nervous (nr) mutant mouse displays two gross recessive traits: both an exaggeration of juvenile hyperactivity and a pronounced ataxia become apparent during the third and fourth postnatal weeks. Using an intersubspecific intercross, we have established a high-resolution map of a segment of mouse chromosome 8 that places the nr locus in a genomic segment defined by D8Rck1 on the centromeric end and D8Mit3 on the telomeric end. This map position places the nr locus within the BALB/cGr congenic region of the C3HeB/ FeJ-nr strain, confirming the accuracy of our study. We used this map position to identify and evaluate three genes-ankyrin 1, cortexin, and farnesyltransferase-as candidates for the nr gene. These three genes were eliminated from consideration but allowed us to establish the conservation of synteny between the region containing the nr locus and a segment of the short arm of human chromosome 8 (8p21-p11.2). Finally, the incomplete penetrance of the nr phenotype led us to perform a screen for modifier loci, and we present evidence that such a nervous modifier locus may exist on mouse chromosome 5.

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Citations

May 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jianxue LiRichard L Sidman
Jun 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dan Goldowitz
May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jianxue LiRichard L Sidman
Jul 13, 2004·The Journal of Comparative Neurology·Cynthia S DuchalaWendy B Macklin
Jul 20, 2005·Experimental Eye Research·Claudia Dalke, Jochen Graw
Feb 22, 2001·Experimental Eye Research·J C RenN S Peachey
Jan 1, 2014·Cerebellum & Ataxias·Jan Cendelin
Dec 18, 2015·Physiological Research·F VoŽeh

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