A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids

Journal of Pharmaceutical and Biomedical Analysis
Csaba Ferenc LaszloCathrin Brisken

Abstract

In the context of hormonal contraception and hormone replacement therapy (HRT), many women are exposed to exogenous hormones. Current use of hormonal contraception with combined ethinyl estradiol and different progestins bestows a breast cancer relative risk (RR) of 1.2- while combined HRT has a RR of 2. Although these exposures present an important public health issue, little is known about the effects of individual progestins on the breast and other tissues. Increasing availability of large scale biobanks, high throughput analyses and data management tools enable ever expanding, sophisticated population studies. In order to address the impact of distinct progestins on various health indicators, it is desirable to accurately quantify progestins in clinical samples. Here we have developed and validated a high resolution liquid chromatography mass spectrometry (LC-MS) targeted method for the simultaneous quantification of 11 synthetic progestins widely used in oral contraceptives, gestodene, levonorgestrel, etonogestrel, chlormadinone acetate, cyproterone acetate, drospirenone, desacetyl norgestimate, medroxyprogesterone acetate, norethindrone, dienogest, nomegestrol acetate, and 4 endogenous steroid hormones, progesterone, test...Continue Reading

Citations

Nov 24, 2020·Biomedical Chromatography : BMC·Amy GravitteStacy Brown
Dec 2, 2020·The Journal of Steroid Biochemistry and Molecular Biology·Eulalia OlestiSerge Rudaz
Dec 15, 2020·Pharmacology & Therapeutics·Alexis J BickJanet P Hapgood
May 28, 2021·EMBO Molecular Medicine·Marie ShamseddinCathrin Brisken

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