A High Salt Diet Modulates the Gut Microbiota and Short Chain Fatty Acids Production in a Salt-Sensitive Hypertension Rat Model

Nutrients
Ariel BierAvshalom Leibowitz

Abstract

Emerging data indicate a correlation between gut microbial composition and cardiovascular disease including hypertension. The host's diet greatly affects microbial composition and metabolite production. Short chain fatty acids (SCFAs) are products of microbial fermentation, which can be utilized by the host. It has been suggested that SCFAs play a pivotal role as mediators in a microbiome host: microbial interactions occur in health and disease. The aim of this study was to evaluate the effect of a high salt diet (HSD) on microbial variation and to determine whether this effect is accompanied by an alteration in fecal SCFAs. To this end, Dahl salt-sensitive rats were divided into two groups (n = 10 each): (A) Control: fed regular chow; and (B) Fed HSD. High-throughput pyrosequencing of the 16S rRNA amplicon sequencing was used for microbiome characterizing. Chromatography-mass spectrometry was used to measure the levels of SCFAs: acetic acid, propionic acid, butyric acid, and isobutyric acid in fecal samples. Differences in microbial composition were noted between groups. Principal Coordinate Analysis (PCoA) principal coordinate 1 (PC1) primarily separated controls from the HSD. Four taxa displayed significant differences betwe...Continue Reading

References

Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Aug 17, 2010·Bioinformatics·Robert C Edgar
Apr 4, 2012·Journal of AOAC International·George T Macfarlane, Sandra Macfarlane
Sep 28, 2012·Genome Biology·Xochitl C MorganCurtis Huttenhower
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jennifer L PluznickMichael J Caplan
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Jul 9, 2014·The Journal of Clinical Investigation·Yael HabermanLee A Denson
Mar 15, 2015·Circulation Research·Martin O'DonnellSalim Yusuf
Apr 2, 2015·Physiological Genomics·Blair MellBina Joe
Oct 7, 2016·Nature Medicine·Bjoern O Schroeder, Fredrik Bäckhed
Mar 21, 2017·Current Hypertension Reports·Jennifer L Pluznick
Aug 25, 2017·Nature Reviews. Cardiology·Francine Z MarquesDavid M Kaye
Nov 17, 2017·Nature·Nicola WilckDominik N Müller
Nov 18, 2017·Annual Review of Physiology·A Justin RuckerSteven D Crowley
Mar 23, 2018·Nature Reviews. Disease Primers·Suzanne OparilPaul K Whelton
Apr 3, 2018·Journal of Visualized Experiments : JoVE·Ayelet Di SegniYael Haberman

❮ Previous
Next ❯

Citations

Feb 4, 2019·Journal of Cellular and Molecular Medicine·Mengchao JinXiang Zhou
Oct 9, 2019·Nutrients·Emanuele RinninellaMaria Cristina Mele
Jan 28, 2020·Microbial Biotechnology·Hui XuLu Cai
Jun 4, 2020·Physiology·Brian G PollJennifer L Pluznick
Jul 3, 2020·American Journal of Hypertension·Iñaki Robles-VeraJuan Duarte
Jun 27, 2019·Current Hypertension Reports·Masami Tanaka, Hiroshi Itoh
Aug 14, 2020·Inflammopharmacology·Marcos Adriano Carlos BatistaLeonardo Máximo Cardoso
Sep 11, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chunying WuLei Wang
Oct 3, 2020·Nutrients·Barbara J H VerhaarMajon Muller
Mar 29, 2020·Clinical Science·Xiao-Feng ChenXiaoqiang Tang
Apr 17, 2020·Scientific Reports·Lorena Calderón-PérezRosa Solà
Oct 5, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Katarina Smiljanec, Shannon L Lennon
Nov 15, 2020·European Journal of Immunology·Stefanie HaaseRalf A Linker
Jan 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Salma NaqviFiroz Anwar
Dec 15, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Qiannan GaoJun Cai
Feb 9, 2021·Briefings in Functional Genomics·Changlu QiLiang Cheng
Feb 5, 2021·Cardiovascular Research·Myungsuk KimBrian J Bennett
Feb 10, 2021·International Journal of Environmental Research and Public Health·Joonatan PalmuTeemu Niiranen
Dec 3, 2020·International Journal of Environmental Research and Public Health·Emanuele RinninellaMaria Cristina Mele
Feb 15, 2020·Journal of the American College of Cardiology·Feng J HeGraham A MacGregor
Dec 12, 2020·Journal of Molecular and Cellular Cardiology·Petra MamicW H Wilson Tang
Jul 9, 2020·Cardiology in Review·Gaia AnselmiLeonarda Galiuto
Jun 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lingyun LuXijie Yu

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

uclust
Galaxy
LEfSe ( Linear discriminant analysis LDA ) Effect Size
Multivariate Association with Linear Models ( MaAsLin )
Maaslin )
R
Agilent Chemstation
Greengenes
QIIME

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.