A high throughput analysis of cytokines and chemokines expression during the course of Trypanosoma cruzi experimental oral infection

Acta Tropica
Adele A RodriguesClaudio V da Silva

Abstract

Trypanosoma cruzi has high biological and biochemical diversity and variable tissue tropism. Here we aimed to verify the kinetics of cytokine and chemokine in situ secretion in animals infected with two distinct T. cruzi strains after oral inoculation. Also, we investigated parasite migration, residence and pathological damage in stomach, heart and spleen. Our results showed that host immune response against T. cruzi infection is an intricate phenomenon that depends on the parasite strain, on the infected organ and on the time point of the infection. We believe that a wide comprehension of host immune response will potentially provide basis for the development of immunotherapeutic strategies in order to clear parasitism and minimize tissue injury. In this context, we find that KC poses as a possible tool to be used.

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Citations

Mar 13, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Pollyana Maria de Oliveira PimentelFabiana Simão Machado
Nov 2, 2021·Frontiers in Cellular and Infection Microbiology·Nadjania Saraiva de Lira SilvaRenato Arruda Mortara

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