A high-yielding preparation of beta-ketonitriles

Organic Letters
Yaohui JiJames V Vowles

Abstract

[reaction: see text] beta-Ketonitriles are important precursors for a wide variety of biologically active heterocycles. A facile procedure for the high-yielding acylation of nitrile anions with unactivated esters to provide beta-ketonitriles is reported. The procedure is successful with enolizable and nonenolizable esters as well as hindered nitrile anions.

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Citations

Jan 26, 2016·The Journal of Organic Chemistry·Mikkel T JensenTroels Skrydstrup
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